{"id":"W2006286058","doi":"10.1007/s11095-004-1188-0","title":"Engineering Polysaccharide-Based Polymeric Micelles to Enhance Permeability of Cyclosporin A Across Caco-2 Cells","year":2005,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Micelle; Polysaccharide; Caco-2; Pharmaceutical technology; Permeability (electromagnetism); Chemistry; Agrégation; Drug carrier; Biophysics; Chemical engineering; Drug delivery; In vitro; Chromatography; Biochemistry; Aqueous solution; Biology; Organic chemistry; Membrane; Immunology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292847,0.000307881,0.000182633,0.0001762352,0.0001291648,0.000396706,0.0001399588,0.0003131208,0.0005697984],"category_scores_gemma":[0.0001649953,0.0001877016,0.0003329418,0.0001568968,0.0001636684,0.0003331669,0.0001758144,0.0005463129,0.0001847668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003791645,"about_ca_system_score_gemma":0.0003148414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006649012,"about_ca_topic_score_gemma":0.001124919,"domain_scores_codex":[0.9999104,0.00002004422,0.000009186403,0.00001247711,0.00002002085,0.0000278752],"domain_scores_gemma":[0.9998974,0.00001974028,0.00003736774,0.000006817402,0.0000152234,0.0000234744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005258436,0.00002187725,0.00002776877,0.00001754213,0.000003829764,0.00001809031,0.000007454806,0.0001512263,0.9990215,0.00008830629,0.00001030662,0.0005795097],"study_design_scores_gemma":[0.00002227692,0.0001309764,0.00024059,0.000002429524,0.0000143929,0.00003621212,0.000005794735,0.0009563551,0.9978694,0.0000138346,0.0007051254,0.000002587602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932104,0.0006708473,0.005124191,0.0001077953,0.00003686908,0.00003841427,0.00005092229,0.00004164504,0.0007189671],"genre_scores_gemma":[0.992018,0.0005749044,0.006088529,0.00004708969,0.000009420002,0.0000174291,0.00006899072,0.00001900296,0.001156391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006649012,"threshold_uncertainty_score":0.002750993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2019748166664326,"score_gpt":0.5717762186772231,"score_spread":0.3698014020107905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}