{"id":"W2006347607","doi":"10.1371/journal.pone.0013288","title":"Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Preeclampsia; Hypoxia-inducible factors; Placenta; Hypoxia (environmental); Hydroxylation; Oxygen tension; Pathogenesis; Gene knockdown; Fetus; Andrology; Biology; Internal medicine; Endocrinology; Chemistry; Medicine; Pregnancy; Enzyme; Oxygen; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558549,0.0001287209,0.0001813977,0.0000389159,0.00005179006,0.00003464048,0.0000791036,0.0001405071,0.00001224826],"category_scores_gemma":[0.0001847687,0.0001250288,0.00003139919,0.00004563796,0.0001233737,0.000006154155,0.000111577,0.0001620597,0.000007550947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003673026,"about_ca_system_score_gemma":0.00004055705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002376404,"about_ca_topic_score_gemma":0.001053994,"domain_scores_codex":[0.9992272,0.00003740441,0.0001475866,0.0002521996,0.0001047657,0.0002308455],"domain_scores_gemma":[0.9995732,0.00001626934,0.00004826906,0.000259498,0.00004327588,0.00005943987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008694814,0.0001115931,0.04177073,0.00004287455,0.00004774878,0.000007590263,0.000285141,5.924953e-7,0.9552302,0.00004964865,0.00006428195,0.002302665],"study_design_scores_gemma":[0.0007967962,0.0001787828,0.7484435,0.00004941586,0.0000697233,0.00004203435,0.00007729152,0.00002295368,0.2439868,0.0007247909,0.005287411,0.0003205182],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971852,0.001280297,0.000008005874,0.000110861,0.0001444589,0.0001401785,0.00003860177,0.00002062418,0.001071825],"genre_scores_gemma":[0.9960771,0.0006442603,0.001654755,0.0001223377,0.000383546,0.000009795623,0.00005191795,0.00001797612,0.001038329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7112433,"threshold_uncertainty_score":0.5098525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703859061162339,"score_gpt":0.2198775994661663,"score_spread":0.2028390088545429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}