{"id":"W2006359840","doi":"10.1021/bi400018h","title":"A Circularly Permuted Photoactive Yellow Protein as a Scaffold for Photoswitch Design","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Photoswitch; Scaffold; Chemistry; Scaffold protein; Photochemistry; Biochemistry; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003281088,0.0003345298,0.0002972273,0.0002019262,0.0001889999,0.0003751731,0.0003536459,0.000468861,0.0006310593],"category_scores_gemma":[0.0003113882,0.0002171555,0.0002177524,0.0002011081,0.0003313131,0.0003578593,0.0003506717,0.0006037146,0.0003707319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004926944,"about_ca_system_score_gemma":0.0002529373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001877383,"about_ca_topic_score_gemma":0.0002635696,"domain_scores_codex":[0.999867,0.00002542392,0.00001165609,0.00003542086,0.00003466127,0.00002586619],"domain_scores_gemma":[0.9998399,0.00002059531,0.00004394252,0.00001842808,0.00002378418,0.00005320942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001124994,0.00007913532,0.0001721844,0.00005930218,0.00001127579,0.0001802045,0.00006795839,0.004184732,0.9842731,0.002759464,0.0001438531,0.00795622],"study_design_scores_gemma":[0.0001006374,0.0009721763,0.0004916187,0.00001419141,0.00002206626,0.0003187534,0.0000446519,0.02787142,0.9584552,0.000993738,0.01068708,0.00002841923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9244573,0.0007194652,0.07094387,0.000313166,0.0001102541,0.0002177196,0.0001495333,0.000560288,0.002528422],"genre_scores_gemma":[0.9622192,0.0005118503,0.03396235,0.00008345072,0.00001120297,0.0001525264,0.0002330231,0.00006643799,0.002759785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006310593,"threshold_uncertainty_score":0.003574729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04825985034768645,"score_gpt":0.2946676420751855,"score_spread":0.246407791727499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}