{"id":"W2006383598","doi":"10.1021/ol027160v","title":"Synthesis of Biologically Active Dicarba Analogues of the Peptide Hormone Oxytocin Using Ring-Closing Metathesis","year":2002,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Ring-closing metathesis; Oxytocin; Peptide; Biological activity; Metathesis; Combinatorial chemistry; Salt metathesis reaction; Stereochemistry; Hormone; Closing (real estate); Peptide hormone; Ring (chemistry); Cyclic peptide; Biochemistry; Organic chemistry; In vitro; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372393,0.0004287768,0.0003330313,0.0001808747,0.0001816452,0.0002548812,0.0004173345,0.0003709875,0.002944766],"category_scores_gemma":[0.0002439745,0.0002223861,0.0002828193,0.0001649679,0.0002135114,0.0002601381,0.0003177153,0.0005750749,0.0008765344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829935,"about_ca_system_score_gemma":0.0001741535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001906478,"about_ca_topic_score_gemma":0.0003868998,"domain_scores_codex":[0.9998416,0.00002460501,0.00001751685,0.00004343359,0.00003172467,0.00004116691],"domain_scores_gemma":[0.9998653,0.00002057745,0.00003933759,0.0000209086,0.00001872013,0.00003518476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000130278,0.00002565643,0.00005332414,0.00009879213,0.00001034272,0.0001268624,0.00003150439,0.0001453435,0.9950756,0.0004799537,0.00009299577,0.003729349],"study_design_scores_gemma":[0.00004456822,0.0008514858,0.0004945759,0.000006158752,0.00002242053,0.0003986655,0.00001322555,0.0002093485,0.9916868,0.00008278624,0.006177455,0.00001255446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680551,0.005308013,0.01144312,0.000248603,0.0001997587,0.0001659083,0.0007807856,0.0002486945,0.01355009],"genre_scores_gemma":[0.9791331,0.002341232,0.01264233,0.000121757,0.00004313112,0.00007545177,0.0005547499,0.00004803462,0.005040269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002944766,"threshold_uncertainty_score":0.009851217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435491262377082,"score_gpt":0.207611111406962,"score_spread":0.1932561987831912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}