{"id":"W2006397899","doi":"10.1016/j.ijporl.2014.02.015","title":"Normal hearing in a child with the m.1555A>G mutation despite repeated exposure to aminoglycosides. Has the penetrance of this pharmacogenetic interaction been overestimated?","year":2014,"lang":"en","type":"article","venue":"International Journal of Pediatric Otorhinolaryngology","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"DNA Genotek","keywords":"Penetrance; Ototoxicity; Aminoglycoside; Medicine; Hearing loss; Audiology; Mutation; Genetics; Internal medicine; Biology; Phenotype; Antibiotics; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003086325,0.001123387,0.0005245319,0.001433058,0.001071939,0.0005949751,0.0008842735,0.00289952,0.001703216],"category_scores_gemma":[0.003684511,0.0004672133,0.0006315712,0.0008145599,0.00171807,0.000632528,0.0007011196,0.001535108,0.0004012572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007642388,"about_ca_system_score_gemma":0.0007332227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01038832,"about_ca_topic_score_gemma":0.00730968,"domain_scores_codex":[0.9995199,0.00008151784,0.00005694016,0.0001243958,0.00008437222,0.0001328344],"domain_scores_gemma":[0.9989465,0.0004872426,0.0002484456,0.00004799775,0.00006073448,0.0002091808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00009039407,0.00004420964,0.03087426,0.00001819928,0.00001274524,0.9644578,0.0003231195,0.00007936378,0.002175025,0.0001810194,0.0003019588,0.001441881],"study_design_scores_gemma":[0.00001847813,0.0002383151,0.04124622,0.00002681569,0.00003896358,0.9564172,0.0005128643,0.0002575135,0.0005956977,0.0002450724,0.0003845314,0.00001821083],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992301,0.0007051763,0.0006207555,0.002385773,0.0001785249,0.00003435951,0.0002106693,0.00004791521,0.003515862],"genre_scores_gemma":[0.9985288,0.0003646897,0.0003803745,0.0003380784,0.000108255,0.000006400081,0.00003744604,0.000009255842,0.0002267582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01038832,"threshold_uncertainty_score":0.02065569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648422396583685,"score_gpt":0.2836669207706889,"score_spread":0.2571826968048521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}