{"id":"W2006409326","doi":"10.1074/jbc.m109.087122","title":"CYR61 Regulates BMP-2-dependent Osteoblast Differentiation through the αvβ3 Integrin/Integrin-linked Kinase/ERK Pathway","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Health Research Institutes; China Medical University; Academia Sinica; National Science Council","keywords":"CYR61; Cell biology; Integrin; MAPK/ERK pathway; Chemistry; Osteoblast; Bone morphogenetic protein; CTGF; Protein kinase A; Signal transduction; Bone morphogenetic protein 2; Osteoclast; Cancer research; Kinase; Biology; Receptor; Growth factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000543383,0.0002804517,0.0003187378,0.00002347015,0.0001462201,0.00008162338,0.0007902128,0.0005162388,0.0005349347],"category_scores_gemma":[0.001419049,0.0001590609,0.000315166,0.0001073984,0.0003232638,0.00001244955,0.0003370593,0.001257158,0.00001515978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004689607,"about_ca_system_score_gemma":0.0001191744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001114404,"about_ca_topic_score_gemma":0.00001789848,"domain_scores_codex":[0.9981872,0.0001329691,0.0005469675,0.0003740101,0.0003710658,0.0003877706],"domain_scores_gemma":[0.9983518,0.0001572095,0.000413466,0.0004701481,0.0004425586,0.0001648679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002509696,0.0001410174,0.004426611,0.00001913394,0.00009241241,0.00002272705,0.00005651532,0.000004935323,0.992416,0.00005124336,0.0003862969,0.002132187],"study_design_scores_gemma":[0.000637422,0.0003767471,0.01558099,0.00002736709,0.00001817606,0.0002331205,0.0002568105,0.00001064844,0.9671487,0.0006135167,0.01488385,0.0002126478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99687,0.0005114691,0.0004149127,0.0006389222,0.0003574524,0.0001588736,0.00002948592,0.00001346086,0.001005456],"genre_scores_gemma":[0.997561,0.0001369974,0.0001904555,0.00008265101,0.001324494,0.00001215341,0.00005753895,0.00002072402,0.0006139769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02526725,"threshold_uncertainty_score":0.6486316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02459326198521167,"score_gpt":0.2794797741330405,"score_spread":0.2548865121478289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}