{"id":"W2006450435","doi":"10.1128/iai.69.1.579-583.2001","title":"Mouse Toxicity and Cytokine Release by Verotoxin 1 B Subunit Mutants","year":2001,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Medical Research Council; Medical Research Council Canada; University of Toronto","keywords":"Biology; Cytotoxicity; Cytokine; Molecular biology; Mutant; Binding site; In vitro; Receptor; In vivo; Toxicity; Biochemistry; Immunology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002823717,0.0002135199,0.0002446334,0.0001058046,0.0005745725,0.00004642544,0.00008524647,0.0002716434,0.0008439619],"category_scores_gemma":[0.0001086462,0.0002023786,0.0000477463,0.0001611737,0.000208478,0.0002429047,0.0001228516,0.0004962203,0.0001343359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003529061,"about_ca_system_score_gemma":0.00001793979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001811015,"about_ca_topic_score_gemma":0.0001110345,"domain_scores_codex":[0.9989078,0.0002642586,0.0002458926,0.0002422064,0.00003323517,0.0003065962],"domain_scores_gemma":[0.9994467,0.00006656824,0.00009271868,0.0002895466,0.00005308188,0.00005135384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001717227,0.0003022863,0.00705679,0.00001035008,0.00006189376,0.000002579234,0.0001586586,3.878246e-7,0.9782873,0.0002061703,0.00116296,0.01257895],"study_design_scores_gemma":[0.003152751,0.0006795198,0.03446255,0.00002796025,0.00004126468,0.000381731,0.0001811329,0.00002448237,0.772709,0.0002456183,0.1876896,0.0004043519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965203,0.001143579,0.0004463876,0.0001036744,0.0003035494,0.0002525368,0.00006426617,0.0001470755,0.001018616],"genre_scores_gemma":[0.9926199,0.003055924,0.00002001501,0.0003274864,0.00001611529,0.00002144076,0.00008531223,0.00001891647,0.003834936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2055783,"threshold_uncertainty_score":0.9240791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073449640719469,"score_gpt":0.2281199220375377,"score_spread":0.217385425630343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}