{"id":"W2006537861","doi":"10.1523/jneurosci.3728-06.2007","title":"Sciatic Nerve Ligation-Induced Proliferation of Spinal Cord Astrocytes Is Mediated by κ Opioid Activation of p38 Mitogen-Activated Protein Kinase","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute on Drug Abuse; U.S. Public Health Service","keywords":"Astrocyte; Glial fibrillary acidic protein; Sciatic nerve; MAPK/ERK pathway; Endocrinology; Dynorphin; Chemistry; Internal medicine; Protein kinase A; Spinal cord; Dynorphin A; Receptor; Kinase; Opioid; Medicine; Biology; Neuroscience; Central nervous system; Immunohistochemistry; Opioid peptide; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008840486,0.000398892,0.0002166415,0.0002320786,0.0001785062,0.0001690641,0.0001186367,0.0001654758,0.00130489],"category_scores_gemma":[0.00007101561,0.0002005596,0.0004127474,0.0001155983,0.0001890379,0.0001667268,0.0002159319,0.0004613386,0.0004281003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321802,"about_ca_system_score_gemma":0.0001743133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006230821,"about_ca_topic_score_gemma":0.00124094,"domain_scores_codex":[0.9998701,0.00001498647,0.00001517334,0.00002267965,0.00003120257,0.00004589462],"domain_scores_gemma":[0.999916,0.000006712089,0.00003104494,0.000008867228,0.000008722414,0.00002874242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001344447,0.00001807032,0.0001254346,0.00003417171,0.000002562362,0.00004689174,0.00001527111,0.000009804598,0.9989424,0.00001846334,0.00001367791,0.0006387559],"study_design_scores_gemma":[0.00003137262,0.0007937911,0.02380184,0.00001876932,0.00002200365,0.000352079,0.00008904507,0.0005053879,0.9730642,0.00004261824,0.001272483,0.000006384063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995146,0.001501371,0.001299343,0.00006398801,0.00002684531,0.00002225087,0.0002540804,0.0000671117,0.001618977],"genre_scores_gemma":[0.9934723,0.001505242,0.001488864,0.00003679646,0.00001660856,0.0000758746,0.0003501971,0.00001051369,0.003043603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130489,"threshold_uncertainty_score":0.004365325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04367934392294076,"score_gpt":0.3021118720078166,"score_spread":0.2584325280848758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}