{"id":"W2006546306","doi":"10.1016/j.ejps.2010.10.001","title":"Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells","year":2010,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation of Korea; National Institute for Health and Care Research","keywords":"Multidrug resistance-associated protein 2; CYP3A4; Chemistry; Caco-2; Transporter; Biochemistry; Metabolism; Cell; ATP-binding cassette transporter; Gene; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000812059,0.0005937698,0.00104363,0.0004516218,0.0004694609,0.0007564123,0.0004946136,0.0008961,0.002262343],"category_scores_gemma":[0.0005936456,0.0005354234,0.0009702875,0.001000399,0.0005958496,0.001059453,0.0002963064,0.001664393,0.0007336805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008154301,"about_ca_system_score_gemma":0.0007493471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003687557,"about_ca_topic_score_gemma":0.002524035,"domain_scores_codex":[0.9990292,0.0004571723,0.00007332231,0.0001032924,0.0001163351,0.000220725],"domain_scores_gemma":[0.9995196,0.0001949584,0.00006087953,0.00007885764,0.00008917106,0.0000566509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005310328,0.0002964216,0.0003072784,0.0002585122,0.0000653221,0.0003930145,0.000310977,0.0004783066,0.9890671,0.0008257527,0.0004170818,0.002269834],"study_design_scores_gemma":[0.0002469498,0.002782613,0.003578418,0.0000189458,0.00009483185,0.0003914796,0.0002054419,0.004176879,0.9843834,0.0002109781,0.00386631,0.0000439012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902169,0.002986384,0.002571482,0.0005482943,0.0001485631,0.00006693141,0.0009040344,0.0001624303,0.002394965],"genre_scores_gemma":[0.9861786,0.001721522,0.004391321,0.0001271705,0.00007089385,0.00009655632,0.002009081,0.0000648288,0.005339972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003687557,"threshold_uncertainty_score":0.0075683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01918248182878175,"score_gpt":0.2917305443092516,"score_spread":0.2725480624804699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}