{"id":"W2006566716","doi":"10.1002/art.23964","title":"Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: Findings of a fifty‐two–week, phase III, multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group study","year":2008,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":577,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Versus Arthritis","keywords":"Certolizumab pegol; Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Methotrexate; Rheumatology; Randomized controlled trial; Gastroenterology; Arthritis; Surgery; Adalimumab; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005095654,0.001229047,0.003174805,0.0005616206,0.0004299839,0.001033093,0.0009885413,0.002043164,0.003171009],"category_scores_gemma":[0.003352765,0.0009023289,0.001751444,0.0004046159,0.001526354,0.001046733,0.0003219011,0.002615041,0.0006076669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000403188,"about_ca_system_score_gemma":0.0007312995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002963247,"about_ca_topic_score_gemma":0.0004426322,"domain_scores_codex":[0.9975056,0.001639803,0.0001911465,0.0002861759,0.0002441695,0.0001332533],"domain_scores_gemma":[0.9974956,0.0009960518,0.0006062675,0.0002423943,0.0001274206,0.000532162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9199781,0.02827254,0.001050247,0.0006680359,0.001369794,0.00006708721,0.0001007387,0.0003723666,0.01962315,0.00005501854,0.0003394296,0.0281035],"study_design_scores_gemma":[0.7758974,0.2167968,0.004366371,0.00003249868,0.0006400927,0.00004757666,0.00001611051,0.000426127,0.00131113,0.00004883993,0.0003997386,0.00001734151],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925756,0.004497573,0.000620797,0.0003557968,0.0003295195,0.0008048511,0.0001481401,0.00008076541,0.0005869388],"genre_scores_gemma":[0.9924859,0.002314869,0.001625348,0.0007510507,0.0007417247,0.0008108479,0.0003359251,0.00002375437,0.0009105541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005095654,"threshold_uncertainty_score":0.02694875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02621123664039309,"score_gpt":0.3207589398457946,"score_spread":0.2945477032054015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}