{"id":"W2006574605","doi":"10.1074/jbc.m701790200","title":"Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"","keywords":"Calcitonin receptor; Receptor; Bimolecular fluorescence complementation; Transmembrane domain; 5-HT5A receptor; Biophysics; Cell biology; G protein-coupled receptor; Transmembrane protein; Biology; Biochemistry; Chemistry; Calcitonin gene-related peptide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009904163,0.0003817238,0.0008385169,0.0001394097,0.0001944346,0.00003137641,0.000531948,0.0004500805,0.0003310072],"category_scores_gemma":[0.00162748,0.0002432156,0.0003874346,0.000848165,0.0006498172,0.0002023286,0.0002089244,0.001116828,0.0000141558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000143314,"about_ca_system_score_gemma":0.0001033128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001872156,"about_ca_topic_score_gemma":5.230757e-7,"domain_scores_codex":[0.9968475,0.0002543041,0.001223715,0.0005462728,0.0005549583,0.0005732279],"domain_scores_gemma":[0.9962305,0.0009477694,0.001988983,0.0002610403,0.0002895883,0.0002820505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001074202,0.0003565363,0.0012561,0.00006639522,0.00005777773,0.000008309166,0.00003972382,0.000009248704,0.9908512,0.0000163515,0.003418216,0.002845898],"study_design_scores_gemma":[0.0008944296,0.0007439873,0.003029083,0.0001153141,0.00002453868,0.0001161171,0.0001711793,0.00001150507,0.9887593,0.00006128497,0.005804234,0.0002690171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998083,0.0004022921,0.00007912124,0.0002535588,0.0003412873,0.0002733909,0.00007326355,0.00002342784,0.0004706466],"genre_scores_gemma":[0.9979907,0.0003284393,0.0003932678,0.0001364148,0.0002808274,0.00001128426,0.000007975182,0.00003160856,0.0008194774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576881,"threshold_uncertainty_score":0.9918046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699520869260974,"score_gpt":0.2608336280454306,"score_spread":0.2238384193528208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}