{"id":"W2006574605","doi":"10.1074/jbc.m701790200","title":"Functional Calcitonin Gene-related Peptide Receptors Are Formed by the Asymmetric Assembly of a Calcitonin Receptor-like Receptor Homo-oligomer and a Monomer of Receptor Activity-modifying Protein-1","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"","keywords":"Calcitonin receptor; Receptor; Bimolecular fluorescence complementation; Transmembrane domain; 5-HT5A receptor; Biophysics; Cell biology; G protein-coupled receptor; Transmembrane protein; Biology; Biochemistry; Chemistry; Calcitonin gene-related peptide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005995096,0.000836282,0.0005206667,0.0004911843,0.0003127863,0.0005938822,0.0006983116,0.0007141145,0.0007772901],"category_scores_gemma":[0.0003245609,0.0002762962,0.0003778252,0.0003636733,0.0005461377,0.0005490138,0.0005257354,0.001094489,0.0006038219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005924103,"about_ca_system_score_gemma":0.0002719663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004023855,"about_ca_topic_score_gemma":0.0004871619,"domain_scores_codex":[0.9992319,0.0001555527,0.00004967233,0.0001847664,0.0002850037,0.00009304178],"domain_scores_gemma":[0.999836,0.00003725219,0.0000499233,0.0000217054,0.00002706505,0.00002800622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001645316,0.000007168638,0.00004293384,0.00002531573,0.000002567495,0.00002433726,0.000009197677,0.00003481168,0.9990734,0.000176972,0.00003143342,0.0005553075],"study_design_scores_gemma":[0.000005139651,0.00003655972,0.000530131,0.000003329716,0.000008358461,0.0002150386,0.00001711917,0.00176969,0.9953966,0.00007126958,0.001939161,0.000007773723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8895937,0.003036625,0.1002106,0.0006105152,0.0001201026,0.0001990435,0.001024495,0.001021838,0.004183054],"genre_scores_gemma":[0.9543942,0.001623892,0.03770874,0.0002923837,0.00002451802,0.000189275,0.001352337,0.000113322,0.004301182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000836282,"threshold_uncertainty_score":0.00429827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03699520869260974,"score_gpt":0.2608336280454306,"score_spread":0.2238384193528208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}