{"id":"W2006591356","doi":"10.1002/gene.20074","title":"Cre recombinase specificity defined by the <i>tau</i> locus","year":2004,"lang":"en","type":"article","venue":"genesis","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Cre recombinase; Biology; Transgene; Recombinase; Locus (genetics); Genetically modified mouse; Allele; Genetics; Gene targeting; Cre-Lox recombination; Molecular biology; Offspring; Reporter gene; Cell biology; Gene; Recombination; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005986599,0.0005448737,0.0004303587,0.0005908298,0.0002645202,0.0006172966,0.0006914414,0.0006088373,0.002633302],"category_scores_gemma":[0.0004588912,0.0003617364,0.000286713,0.0002924407,0.0005816383,0.0004149475,0.0004992594,0.001042331,0.00188938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259924,"about_ca_system_score_gemma":0.0003042575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003154886,"about_ca_topic_score_gemma":0.0004733765,"domain_scores_codex":[0.9994874,0.00009344264,0.00007486599,0.0001476138,0.0001070612,0.00008955331],"domain_scores_gemma":[0.9996345,0.00006688041,0.0001222919,0.00005432855,0.0000515435,0.00007045417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004364218,0.000009793617,0.00007419559,0.00002552617,0.000001877652,0.00006834573,0.00002138607,0.00002582628,0.9972891,0.0005489184,0.00008399832,0.001807365],"study_design_scores_gemma":[0.00003462093,0.000133439,0.0009212647,0.0000191215,0.00002143697,0.00166628,0.00002415271,0.0004847766,0.9806669,0.0001966734,0.01582164,0.000009795978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.719278,0.005225383,0.2477981,0.0007010627,0.0004419494,0.001186746,0.002600244,0.002242846,0.02052568],"genre_scores_gemma":[0.8340515,0.005720692,0.1350785,0.0004867334,0.0001530602,0.001051322,0.003248002,0.0007670583,0.01944307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002633302,"threshold_uncertainty_score":0.008809268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03137504240883405,"score_gpt":0.2297348176807119,"score_spread":0.1983597752718778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}