{"id":"W2006609658","doi":"10.1110/ps.03138803","title":"Binding‐induced folding transitions in calpastatin subdomains A and C","year":2003,"lang":"en","type":"article","venue":"Protein Science","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hungarian Scientific Research Fund; Queen's University; Wellcome Trust","keywords":"Calpastatin; Chemistry; Calpain; Biophysics; Protein folding; Binding site; Folding (DSP implementation); Entropy (arrow of time); Enzyme; Biochemistry; Biology; Physics; Thermodynamics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005823963,0.00006106195,0.00004830741,0.00009801181,0.0001570494,0.00003289153,0.00005537641,0.00004148356,0.00001283881],"category_scores_gemma":[0.0001850814,0.00005732165,0.00001618385,0.0003305765,0.0001511438,0.000009496961,0.00001635602,0.00004753009,0.00000252231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001811056,"about_ca_system_score_gemma":0.0001051058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009648263,"about_ca_topic_score_gemma":0.00003667243,"domain_scores_codex":[0.9993092,0.00004702579,0.00009900467,0.0002559082,0.0001197861,0.0001690518],"domain_scores_gemma":[0.9997643,0.000002962766,0.00002571072,0.0001071562,0.00003338555,0.00006644546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007663435,0.00001659963,0.0006001915,0.000004534305,8.255862e-7,8.366499e-7,0.00009384408,0.00001131766,0.9956515,0.002374748,0.000005316221,0.001232591],"study_design_scores_gemma":[0.0005416943,0.0001208675,0.004571664,0.00002488499,0.000002061081,0.00002072625,0.0002632014,0.0003769202,0.9913993,0.0006075333,0.001920333,0.0001508481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929959,0.00004800383,0.005673917,0.0001872935,0.00004187437,0.0003247403,0.000001744283,0.000007047961,0.0007194548],"genre_scores_gemma":[0.9976545,0.000002816571,0.002004985,0.00004713278,0.00001408986,0.00005054649,0.000002717584,0.000004466018,0.0002187443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004658577,"threshold_uncertainty_score":0.2337509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159389318001853,"score_gpt":0.2516438304899329,"score_spread":0.2400499373099144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}