{"id":"W2006609658","doi":"10.1110/ps.03138803","title":"Binding‐induced folding transitions in calpastatin subdomains A and C","year":2003,"lang":"en","type":"article","venue":"Protein Science","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hungarian Scientific Research Fund; Queen's University; Wellcome Trust","keywords":"Calpastatin; Chemistry; Calpain; Biophysics; Protein folding; Binding site; Folding (DSP implementation); Entropy (arrow of time); Enzyme; Biochemistry; Biology; Physics; Thermodynamics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193924,0.000174194,0.0001583169,0.0001022752,0.0001573173,0.0001858038,0.0001597632,0.0001948967,0.0004805777],"category_scores_gemma":[0.0003023054,0.00008061502,0.0001632683,0.0001163239,0.0002337406,0.000157794,0.0001044754,0.0003030011,0.0001055881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00030007,"about_ca_system_score_gemma":0.0001694907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008062134,"about_ca_topic_score_gemma":0.0006483424,"domain_scores_codex":[0.9999173,0.00001476361,0.0000054269,0.00002363109,0.00002032342,0.00001859156],"domain_scores_gemma":[0.9997901,0.00006824754,0.00005693573,0.00001467633,0.0000254949,0.00004445876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001979755,0.00003674993,0.001008181,0.00002160166,0.000007528729,0.00009251267,0.00003448279,0.0003801565,0.9970681,0.0001718971,0.00003702845,0.0009437623],"study_design_scores_gemma":[0.00007661668,0.0005453181,0.02963734,0.00000900736,0.0000157921,0.0004669052,0.0000596788,0.006037198,0.9616148,0.0002990903,0.001220323,0.00001804544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986022,0.0001763284,0.0008071481,0.00001497135,0.000003586408,0.000008493306,0.00005044661,0.00001120084,0.0003257108],"genre_scores_gemma":[0.9988949,0.00006463449,0.0006837269,0.00002740137,0.000001770344,0.00001016385,0.0001226339,0.000003971315,0.0001907292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008062134,"threshold_uncertainty_score":0.002177119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159389318001853,"score_gpt":0.2516438304899329,"score_spread":0.2400499373099144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}