{"id":"W2006615927","doi":"10.1124/dmd.105.005488","title":"HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs","funders":"Canadian Institutes of Health Research","keywords":"Genetically modified mouse; Biology; Transgene; Humanized mouse; Kidney; CYP2D6; Cytochrome P450; Molecular biology; Enzyme; In vivo; Biochemistry; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007367996,0.0003656813,0.0004565195,0.0001946116,0.0004474086,0.00008079177,0.0001688137,0.0002599483,0.0001345409],"category_scores_gemma":[0.00002585186,0.0003661076,0.00007689084,0.0002068137,0.0002105205,0.0004174028,0.0001410235,0.0005805407,0.00002704694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004996223,"about_ca_system_score_gemma":0.00003591456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006869368,"about_ca_topic_score_gemma":0.00009900228,"domain_scores_codex":[0.9978525,0.0003553262,0.0005178985,0.0005385933,0.0001994259,0.0005362712],"domain_scores_gemma":[0.9991375,0.00005383478,0.0001502026,0.0002077452,0.00008416128,0.0003666071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004170481,0.0009943151,0.001953802,0.00008378248,0.0001080059,0.00001252137,0.004144379,0.002636079,0.9238439,0.03496782,0.001804123,0.02903427],"study_design_scores_gemma":[0.02255527,0.00007052365,0.03217636,0.00004204911,0.001221927,0.00004838651,0.0006786238,0.1650335,0.6722746,0.007027895,0.09681259,0.002058289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921255,0.004622854,0.0004840497,0.0006934538,0.0001808603,0.0004903481,0.0006112949,0.0001055079,0.0006860919],"genre_scores_gemma":[0.9936278,0.002326858,0.0003367687,0.001492811,0.0003938499,0.00008251748,0.000438475,0.00004090605,0.001259966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2515693,"threshold_uncertainty_score":0.9998791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04104609317897825,"score_gpt":0.3710906995961201,"score_spread":0.3300446064171419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}