{"id":"W2006615927","doi":"10.1124/dmd.105.005488","title":"HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs","funders":"Canadian Institutes of Health Research","keywords":"Genetically modified mouse; Biology; Transgene; Humanized mouse; Kidney; CYP2D6; Cytochrome P450; Molecular biology; Enzyme; In vivo; Biochemistry; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009895806,0.001385247,0.0009700495,0.002452118,0.0004284581,0.000913444,0.0007099599,0.0010549,0.002646812],"category_scores_gemma":[0.0003292161,0.0007779203,0.001011121,0.0009089914,0.0009939455,0.00111752,0.0003551492,0.002587412,0.001039107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008520631,"about_ca_system_score_gemma":0.0005369577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398791,"about_ca_topic_score_gemma":0.001700667,"domain_scores_codex":[0.9992408,0.0001523063,0.00004924984,0.0002783345,0.0001829417,0.00009643588],"domain_scores_gemma":[0.999471,0.0000738617,0.0001641766,0.0001311331,0.00004369014,0.0001161101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005840129,0.001132507,0.001350134,0.00007703046,0.00008528405,0.0003137989,0.00009188223,0.0006977643,0.9817804,0.001071195,0.0007210936,0.006838812],"study_design_scores_gemma":[0.0005334921,0.006250693,0.006177528,0.00001952485,0.0003600246,0.002245788,0.0001227609,0.004859751,0.9684552,0.0005787259,0.01035006,0.00004644638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514779,0.003635241,0.03570693,0.0006964204,0.0001745861,0.0002937034,0.003919611,0.0009429427,0.003152791],"genre_scores_gemma":[0.9567594,0.003529719,0.0169401,0.0003320025,0.00008366653,0.0006103265,0.004380438,0.0004501284,0.01691416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002646812,"threshold_uncertainty_score":0.008854449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04104609317897825,"score_gpt":0.3710906995961201,"score_spread":0.3300446064171419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}