{"id":"W2006654830","doi":"10.1111/j.1538-7836.2009.03551.x","title":"An assessment of the pathogenic significance of the R924Q von Willebrand factor substitution","year":2009,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute","keywords":"Von Willebrand factor; Haplotype; Compound heterozygosity; Von Willebrand disease; Exon; Heterozygote advantage; Molecular biology; Allele; In vitro; Biology; RNA splicing; Genotype; Pathogenesis; Genetics; Gene; RNA; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006219039,0.0007932807,0.0003814125,0.0009790205,0.000552972,0.0004691654,0.0005186959,0.001851238,0.006192371],"category_scores_gemma":[0.001793604,0.0001833026,0.000489469,0.0004293763,0.0007250327,0.0002446283,0.0003312518,0.0007456168,0.0008354616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002706326,"about_ca_system_score_gemma":0.0002569508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008519807,"about_ca_topic_score_gemma":0.0003435433,"domain_scores_codex":[0.9994397,0.0001607518,0.0000751476,0.00009697085,0.0001381115,0.00008933058],"domain_scores_gemma":[0.999379,0.0003252695,0.00008365043,0.00004352805,0.00008912613,0.00007941707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004855726,0.0005565686,0.06533943,0.0001867426,0.0002700349,0.05290804,0.0007830241,0.001684039,0.8428024,0.004024281,0.001339541,0.02525016],"study_design_scores_gemma":[0.002003294,0.01234878,0.2007454,0.0001751465,0.001375859,0.2449367,0.001717478,0.0173832,0.4747869,0.00645764,0.03787819,0.0001913008],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935753,0.0006279725,0.0011515,0.0005248826,0.00007406317,0.0000526255,0.0003570514,0.00003704683,0.003599781],"genre_scores_gemma":[0.9983318,0.0001254384,0.000638171,0.0001332157,0.00003088779,0.000009495349,0.0001466851,0.00001188305,0.000572357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006192371,"threshold_uncertainty_score":0.02071548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911173434500918,"score_gpt":0.3500212207864787,"score_spread":0.3109094864414695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}