{"id":"W2006656322","doi":"10.1038/nchembio.120","title":"Combination chemical genetics","year":2008,"lang":"en","type":"review","venue":"Nature Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs; University of New Brunswick","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Chemical genetics; Computational biology; Systems biology; Living systems; Biology; Genetic screen; Mutant; Phenotype; Chemical biology; Gene; Small molecule; Genetics; Computer science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001262943,0.0005922922,0.001157434,0.00008057873,0.00005289003,0.00001371451,0.0007683859,0.005649102,0.00004641771],"category_scores_gemma":[0.0003940521,0.0004845315,0.0006493888,0.0001667762,0.0002189693,0.000001474105,0.0003278877,0.0009972302,0.00008302639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005546404,"about_ca_system_score_gemma":0.0002142557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.533331e-7,"about_ca_topic_score_gemma":1.83003e-7,"domain_scores_codex":[0.9976736,0.0001844987,0.0005334758,0.0009395321,0.0001438413,0.0005250875],"domain_scores_gemma":[0.9986724,0.00008599595,0.0002877784,0.0006773522,0.000105121,0.0001713778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001800511,0.00008602155,0.000001485575,0.0006478233,0.0001607155,0.000006289729,0.000002277988,1.097208e-8,0.2263698,0.0004891203,0.004074359,0.7681441],"study_design_scores_gemma":[0.0001729011,0.00007821977,7.251186e-8,0.0002506699,0.00009175859,0.0001991574,5.053678e-7,3.116826e-7,0.1827346,0.0003082836,0.8157238,0.0004397898],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003386282,0.9974521,0.00009872237,0.00003426575,0.0004728177,0.0004927447,0.00008936423,0.00003632818,0.0009849753],"genre_scores_gemma":[0.000678491,0.9929784,0.001346032,0.0002412115,0.001071598,0.0001328773,0.003293413,0.00008538163,0.0001725959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8116494,"threshold_uncertainty_score":0.9997606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688307750160812,"score_gpt":0.3064984977087553,"score_spread":0.2896154202071471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}