{"id":"W2006656322","doi":"10.1038/nchembio.120","title":"Combination chemical genetics","year":2008,"lang":"en","type":"review","venue":"Nature Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs; University of New Brunswick","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Chemical genetics; Computational biology; Systems biology; Living systems; Biology; Genetic screen; Mutant; Phenotype; Chemical biology; Gene; Small molecule; Genetics; Computer science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007864622,0.00153344,0.001600554,0.001775883,0.0006899981,0.001471802,0.002365966,0.001806027,0.008154999],"category_scores_gemma":[0.0005977129,0.0008236726,0.0006907116,0.001709916,0.002327509,0.002130539,0.002246129,0.004414005,0.007559219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001729521,"about_ca_system_score_gemma":0.001040035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008149376,"about_ca_topic_score_gemma":0.001551014,"domain_scores_codex":[0.9994849,0.00007075508,0.00002670565,0.0001347255,0.0002346182,0.00004836032],"domain_scores_gemma":[0.9997576,0.00009020486,0.00001791878,0.00004790597,0.00006159349,0.00002483102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000104259,0.0001115998,0.0001791505,0.003365189,0.00009480059,0.0004016223,0.00006192771,0.001257197,0.01904286,0.1236859,0.08658165,0.7651138],"study_design_scores_gemma":[0.00001550056,0.00002502719,0.00009786812,0.000196479,0.00002355398,0.0007167939,0.000008548172,0.000272416,0.005799208,0.01522532,0.9775984,0.00002087584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001360138,0.8215515,0.06312271,0.003251611,0.008106519,0.0001255014,0.0002107623,0.0006715107,0.1015998],"genre_scores_gemma":[0.02272098,0.8301026,0.03882835,0.006167633,0.00305488,0.0003834577,0.0005446326,0.0002079251,0.09798952],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008154999,"threshold_uncertainty_score":0.02728117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01688307750160812,"score_gpt":0.3064984977087553,"score_spread":0.2896154202071471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}