{"id":"W2006698365","doi":"10.1002/prot.20367","title":"Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins","year":2004,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Nonsynonymous substitution; Biology; Genetics; Single-nucleotide polymorphism; Population; Computational biology; Function (biology); SNP; Gene; Genome; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005493267,0.0001510667,0.0001106925,0.00005188617,0.0002641151,0.00005316776,0.00007000729,0.00008001411,0.00001614636],"category_scores_gemma":[0.00001967443,0.00009848241,0.000053926,0.00007915663,0.0001206281,0.00001399457,0.00008147173,0.0001109314,0.000001172868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001243556,"about_ca_system_score_gemma":0.00007184787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001153243,"about_ca_topic_score_gemma":0.0007013414,"domain_scores_codex":[0.9994205,0.00001746289,0.0001819879,0.0001366292,0.00009627588,0.0001471263],"domain_scores_gemma":[0.9994909,0.000006005304,0.0001439801,0.0002183922,0.0000591586,0.00008153484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007693855,0.0002889138,0.0078725,0.001210291,0.0004987763,0.000003314166,0.002718986,0.001657986,0.95535,0.001647119,0.001026468,0.02695623],"study_design_scores_gemma":[0.007578466,0.003660142,0.06185443,0.0002305985,0.0007223784,0.0005841982,0.01233494,0.001789554,0.862422,0.006446792,0.04072037,0.001656062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909737,0.000295174,0.006725886,0.0003006367,0.0002029364,0.0006856414,0.0002614288,0.00001406918,0.000540524],"genre_scores_gemma":[0.9978372,0.000108621,0.001439628,0.0001805014,0.00007958777,0.00003105073,0.0001589311,0.00001085948,0.0001536182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09292796,"threshold_uncertainty_score":0.4015996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004760003513867476,"score_gpt":0.2000339098719689,"score_spread":0.1952739063581014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}