{"id":"W2006698365","doi":"10.1002/prot.20367","title":"Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins","year":2004,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Nonsynonymous substitution; Biology; Genetics; Single-nucleotide polymorphism; Population; Computational biology; Function (biology); SNP; Gene; Genome; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000612291,0.0003831513,0.0005674352,0.001969985,0.0005342252,0.0004107794,0.0002954776,0.0004445102,0.002263848],"category_scores_gemma":[0.002116436,0.0001227693,0.0008806176,0.002385487,0.0003509483,0.0001771521,0.0003600056,0.0003093197,0.0003434407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084484,"about_ca_system_score_gemma":0.0004909479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223398,"about_ca_topic_score_gemma":0.003108976,"domain_scores_codex":[0.9993804,0.0001252466,0.0001190559,0.0001780405,0.0001278241,0.00006953397],"domain_scores_gemma":[0.998551,0.0007672798,0.0004460341,0.00008095161,0.00006512042,0.00008967818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001815964,0.0001562158,0.87194,0.0008598903,0.001569525,0.004984095,0.0003398896,0.003692427,0.0677157,0.001344886,0.001828854,0.04375263],"study_design_scores_gemma":[0.000107054,0.000214293,0.9581803,0.0001649686,0.001144232,0.006979424,0.0002696653,0.01201299,0.0118697,0.001942576,0.007070404,0.00004442594],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921502,0.001328495,0.003140336,0.00004655824,0.00002787965,0.00004419782,0.00266434,0.00004709776,0.0005508999],"genre_scores_gemma":[0.9908277,0.0003606509,0.003753321,0.00005888368,0.00001930673,0.00003826423,0.004691926,0.00002223524,0.0002277405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002263848,"threshold_uncertainty_score":0.007573307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004760003513867476,"score_gpt":0.2000339098719689,"score_spread":0.1952739063581014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}