{"id":"W2006724685","doi":"10.1016/j.ymgme.2007.09.017","title":"Recommendations for evaluation of responsiveness to tetrahydrobiopterin (BH4) in phenylketonuria and its use in treatment","year":2007,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Hyperphenylalaninemia; Tetrahydrobiopterin; Phenylalanine hydroxylase; Phenylalanine; Medicine; Phenylketonurias; Internal medicine; Pediatrics; Endocrinology; Biochemistry; Chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009133242,0.0001660641,0.0002289567,0.0002287845,0.00002605781,0.00001915437,0.00007317909,0.0001086522,0.000004203206],"category_scores_gemma":[0.0001838444,0.0001699823,0.00004350446,0.0001685977,0.00002875557,0.000004955843,0.00005825393,0.000029919,2.890202e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000079146,"about_ca_system_score_gemma":0.00007314426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007272625,"about_ca_topic_score_gemma":0.0006793044,"domain_scores_codex":[0.9987859,0.0001222652,0.0003378505,0.0003767795,0.0001315856,0.0002456371],"domain_scores_gemma":[0.999421,0.00002730446,0.00006363627,0.0002254177,0.0001634008,0.00009924152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002730574,0.0001501673,0.002488388,0.00001803549,0.00003946785,0.000002068976,0.0003354682,0.001027461,0.9286966,0.0006940997,0.00001943961,0.06625576],"study_design_scores_gemma":[0.00563157,0.0002764832,0.2454852,0.00002839079,0.0001363525,0.000005908908,0.0001879599,0.0008301968,0.6779319,0.00054169,0.06859642,0.0003479347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855248,0.01113207,0.002020971,0.0001398661,0.000126966,0.0009401153,0.00005322306,0.000001929436,0.00006011756],"genre_scores_gemma":[0.9924742,0.001778345,0.005345634,0.0001453615,0.00002807384,0.0000881502,0.00007084087,0.00002071773,0.00004867468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2507647,"threshold_uncertainty_score":0.6931676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03568676677111003,"score_gpt":0.3265868822653025,"score_spread":0.2909001154941924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}