{"id":"W2006796554","doi":"10.1016/s0014-2999(00)00636-1","title":"Inverse agonism by Dmt–Tic analogues and HS 378, a naltrindole analogue","year":2000,"lang":"en","type":"article","venue":"European Journal of Pharmacology","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Naltrindole; Inverse agonist; Chemistry; Antagonist; Stereochemistry; Partial agonist; Agonist; GTPgammaS; Receptor antagonist; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241878,0.0004006359,0.0005001763,0.0002817637,0.0002868743,0.0002905254,0.0003591597,0.0003827917,0.00690722],"category_scores_gemma":[0.0005058704,0.0002832721,0.000292164,0.0001988543,0.0004446058,0.0003087249,0.0002299943,0.001061689,0.0008063322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005270799,"about_ca_system_score_gemma":0.0005279721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002611991,"about_ca_topic_score_gemma":0.006359007,"domain_scores_codex":[0.9997719,0.00006599019,0.00001869501,0.0000225498,0.00003035055,0.00009041604],"domain_scores_gemma":[0.9998078,0.00006665975,0.00002779947,0.00002179402,0.00001758442,0.00005841712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01346966,0.0003756707,0.0004302749,0.000326493,0.00006252562,0.0005405156,0.0002320868,0.0007445257,0.968416,0.001405959,0.0009591807,0.01303704],"study_design_scores_gemma":[0.002540632,0.02128204,0.01215072,0.00009174296,0.0002034106,0.002331551,0.0005126778,0.006610651,0.940317,0.0005873137,0.01328413,0.00008803495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841633,0.001209618,0.0008052609,0.0002696354,0.0000815465,0.0001307994,0.0004563693,0.00008428758,0.01279911],"genre_scores_gemma":[0.9916088,0.001089467,0.001197565,0.0001468562,0.00006312625,0.00005289613,0.0006416316,0.00001769223,0.005181918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00690722,"threshold_uncertainty_score":0.02310699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527220001811899,"score_gpt":0.2725296116672406,"score_spread":0.2472574116491216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}