{"id":"W2006848427","doi":"10.1016/j.celrep.2013.08.035","title":"Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9","year":2013,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ministero dello Sviluppo Economico; Centre National de la Recherche Scientifique; Wellcome Trust; Agence Nationale de la Recherche; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Eli Lilly and Company; European Molecular Biology Laboratory; Ontario Genomics; Genome Canada; European Synchrotron Radiation Facility; GlaxoSmithKline; Pfizer","keywords":"Histone methyltransferase; Histone H3; Histone H2A; Histone; Histone octamer; EZH2; Histone methylation; Chemistry; Biochemistry; Cell biology; Biology; Nucleosome; Gene expression; DNA; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115604,0.0002184546,0.000254616,0.0001118042,0.0002282291,0.0003513668,0.0005272442,0.0003238555,0.001116002],"category_scores_gemma":[0.0001832759,0.0001991898,0.0002685932,0.00009593458,0.0004192568,0.0002369807,0.0002936773,0.0006117816,0.000425433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004982394,"about_ca_system_score_gemma":0.0002456237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000994224,"about_ca_topic_score_gemma":0.000844824,"domain_scores_codex":[0.9999068,0.00001096771,0.000008417292,0.00002301872,0.0000289333,0.00002177623],"domain_scores_gemma":[0.9999073,0.00001822544,0.00002435332,0.00001448073,0.00001487554,0.00002078522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334777,0.00001668313,0.000763159,0.0000264724,0.000007031472,0.0001379964,0.00001131087,0.0004199072,0.9967663,0.0006928377,0.00004656412,0.0009782125],"study_design_scores_gemma":[0.00004843311,0.00007747197,0.01075813,0.000004394995,0.00001417562,0.000281148,0.00003034679,0.005604349,0.9810183,0.0007409903,0.001410809,0.00001151665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925675,0.001169387,0.003882665,0.0002648101,0.00004098083,0.00001779753,0.0002427762,0.0001065751,0.001707534],"genre_scores_gemma":[0.9975267,0.0003147596,0.00126411,0.00003304286,0.000007343745,0.000008007889,0.0001795361,0.00001134466,0.0006551179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001116002,"threshold_uncertainty_score":0.003733397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009407254281219132,"score_gpt":0.2354647269009845,"score_spread":0.2260574726197654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}