{"id":"W2006848427","doi":"10.1016/j.celrep.2013.08.035","title":"Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9","year":2013,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ministero dello Sviluppo Economico; Centre National de la Recherche Scientifique; Wellcome Trust; Agence Nationale de la Recherche; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Eli Lilly and Company; European Molecular Biology Laboratory; Ontario Genomics; Genome Canada; European Synchrotron Radiation Facility; GlaxoSmithKline; Pfizer","keywords":"Histone methyltransferase; Histone H3; Histone H2A; Histone; Histone octamer; EZH2; Histone methylation; Chemistry; Biochemistry; Cell biology; Biology; Nucleosome; Gene expression; DNA; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769229,0.0000736838,0.00009362967,0.00001268857,0.00004559033,0.000005987935,0.00008215791,0.00008195594,0.00001581434],"category_scores_gemma":[0.0001488561,0.0000456493,0.0001466783,0.00006256287,0.00006293372,0.000002636035,0.00003036738,0.00003274285,1.874899e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004576286,"about_ca_system_score_gemma":0.00006153786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008177378,"about_ca_topic_score_gemma":0.000007298613,"domain_scores_codex":[0.9993542,0.00004989306,0.000225484,0.0001613954,0.0001212701,0.00008768673],"domain_scores_gemma":[0.9990289,0.00004418891,0.0002169078,0.0005138341,0.0001748066,0.00002137872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009589801,0.00003362259,0.001789052,0.00002997429,0.00001969722,1.382866e-7,0.00002159035,0.0007936904,0.9937554,0.00001700788,0.00006437473,0.003465887],"study_design_scores_gemma":[0.0000776037,0.00005894574,0.03133461,0.000005498643,0.00003159733,0.000001059525,0.000009717747,0.0001831851,0.9657684,0.0005247894,0.001953664,0.0000509196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776589,0.0008652537,0.0197984,0.0001265035,0.0001214232,0.0005495725,0.000004447424,0.000001934988,0.0008735368],"genre_scores_gemma":[0.9991553,0.00006475618,0.0004418555,0.00001786308,0.00002965344,0.00004682676,0.000009278092,0.00001106061,0.000223337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02954556,"threshold_uncertainty_score":0.1861524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009407254281219132,"score_gpt":0.2354647269009845,"score_spread":0.2260574726197654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}