{"id":"W2006850678","doi":"10.3899/jrheum.110777","title":"Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes — Possible Pathogenic Role in Osteoarthritis","year":2012,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ADAMTS; MAPK/ERK pathway; Crosstalk; Matrix metalloproteinase; Medicine; Osteoarthritis; Thrombospondin; Downregulation and upregulation; Cartilage; Cell biology; Metalloproteinase; MMP1; Cancer research; Signal transduction; Internal medicine; Chemistry; Pathology; Biology; Anatomy; Biochemistry; Gene expression","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553836,0.0004835471,0.0003160411,0.0003615415,0.0002246253,0.0002971392,0.0001427643,0.0002610745,0.001493781],"category_scores_gemma":[0.0001355001,0.0001938866,0.0003910584,0.0001705532,0.0002821156,0.0002226644,0.0002766119,0.0003678926,0.0002084776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000146874,"about_ca_system_score_gemma":0.0002141947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000264091,"about_ca_topic_score_gemma":0.0003739286,"domain_scores_codex":[0.9997721,0.00004695938,0.00002930373,0.00002812697,0.00006402947,0.00005952469],"domain_scores_gemma":[0.999894,0.000009594427,0.00004076354,0.000007712287,0.00001427628,0.00003353146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005974175,0.00006002995,0.002345767,0.0001244844,0.00001610933,0.0006064537,0.0000519516,0.00002531791,0.9947231,0.00005924543,0.00002600141,0.001364258],"study_design_scores_gemma":[0.000151567,0.001790978,0.1339722,0.00003407771,0.0001619543,0.006161797,0.00049305,0.001284888,0.8525684,0.0002642835,0.00310219,0.00001467067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946283,0.003823752,0.0008322599,0.00005926951,0.00001772,0.0000216261,0.0000649561,0.00001409811,0.0005381615],"genre_scores_gemma":[0.997575,0.0009419369,0.0005661893,0.00002257758,0.00001332935,0.0000297133,0.00008934923,0.000001907981,0.000760068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493781,"threshold_uncertainty_score":0.004997194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007040225372198262,"score_gpt":0.231928549777196,"score_spread":0.2248883244049977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}