{"id":"W2006867673","doi":"10.1016/j.drudis.2015.01.008","title":"Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA","year":2015,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"cccDNA; Hepatitis B virus; Circular DNA; Virology; Virus; Cirrhosis; Hepatitis B; Medicine; Biology; Immunology; Genome; HBsAg; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004435069,0.0006385929,0.001198817,0.001925965,0.0001999934,0.0006645363,0.0006724419,0.0007618756,0.002043018],"category_scores_gemma":[0.0005876399,0.000273929,0.0005947764,0.001470736,0.0003768967,0.0009929305,0.0003975925,0.001181091,0.0007681403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369358,"about_ca_system_score_gemma":0.0007448135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008833614,"about_ca_topic_score_gemma":0.001881319,"domain_scores_codex":[0.9998664,0.00002093844,0.00002189087,0.00002286909,0.00005403965,0.00001389698],"domain_scores_gemma":[0.9997073,0.0001691667,0.00004881713,0.000005853311,0.00004827293,0.0000204945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000122019,0.00008967023,0.0002004558,0.03761676,0.0001493214,0.0002193263,0.00005718032,0.0003328052,0.005275455,0.002226107,0.02013556,0.9335754],"study_design_scores_gemma":[0.00004611991,0.0002674428,0.001016002,0.005941155,0.0003483245,0.001802266,0.00007865098,0.0001810264,0.002090342,0.001619132,0.9865685,0.00004099182],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001099755,0.999331,0.00009134998,0.00009480216,0.00007667522,0.00000343434,0.00001068666,0.000004134944,0.0002778453],"genre_scores_gemma":[0.0005250996,0.9989161,0.0001678503,0.0001234047,0.00006706916,0.000003233014,0.00001489909,6.056773e-7,0.0001817211],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002043018,"threshold_uncertainty_score":0.006834567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04918516439325137,"score_gpt":0.3410665397478135,"score_spread":0.2918813753545621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}