{"id":"W2006871610","doi":"10.1371/journal.pone.0114614","title":"Replication Attempt: “Effect of BMAP-28 Antimicrobial Peptides on Leishmania Major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival”","year":2014,"lang":"en","type":"letter","venue":"PLoS ONE","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; McMaster University; Broad Institute; Washington University in St. Louis; Stanford Bio-X; University of Miami; Oregon Health and Science University","keywords":"Amastigote; Leishmania; Antimicrobial; Biology; Microbiology; Leishmania major; Antimicrobial peptides; Peptide; Antiparasitic; Cathelicidin; In vitro; Antiparasitic agent; Parasite hosting; Pharmacology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":{"n_in":3,"stratum":"fund_new","weight":1678.9,"opus":{"tier":"T1","genre":"empirical","about_ca":false,"confidence":"low","reason":"A direct replication submitted to the Reproducibility Initiative to independently validate a published result; framed as reproducibility work, though its immediate object is a specific biological claim."},"gpt":{"tier":"T1","genre":"empirical","about_ca":false,"confidence":"high","reason":"This reports an attempted replication and independent validation of prior experiments, making reproducibility the object of study."},"grok":{"tier":"T1","genre":"empirical","about_ca":false,"confidence":"high","reason":"Independent replication attempt submitted to the Reproducibility Initiative; primary object is whether prior results replicate."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.02066976,0.00148786,0.0009733861,0.0004352503,0.003279253,0.003520824,0.0039984,0.02879104,0.004647432],"category_scores_gemma":[0.06819083,0.0004796878,0.001895707,0.0002696143,0.002280893,0.001612222,0.003229782,0.01772721,0.007300566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004428616,"about_ca_system_score_gemma":0.002901306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148836,"about_ca_topic_score_gemma":0.0007564058,"domain_scores_codex":[0.9812407,0.006473804,0.002415721,0.002642336,0.00603252,0.001194859],"domain_scores_gemma":[0.9589635,0.01406548,0.002885226,0.005027329,0.01626853,0.002789963],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002379614,0.0007974306,0.002966185,0.0006883055,0.0002891844,0.01427264,0.00182743,0.0002331826,0.02467147,0.01383674,0.9033859,0.03465188],"study_design_scores_gemma":[0.0008550552,0.002795073,0.00390673,0.0002745295,0.0002944027,0.005087061,0.0010333,0.002240338,0.02981062,0.004917278,0.948508,0.0002774851],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01506378,0.002224122,0.006356631,0.6955645,0.2672633,0.001645407,0.0004840001,0.0005383331,0.01085996],"genre_scores_gemma":[0.08607843,0.002201027,0.01000934,0.644691,0.1968005,0.003409529,0.0007741895,0.0003414578,0.05569444],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9793302,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03468581993067017,"score_gpt":0.2692734260164546,"score_spread":0.2345876060857844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}