{"id":"W2006884048","doi":"10.1158/1535-7163.targ-11-a194","title":"Abstract A194: A QT/QTc and multi-dose pharmacokinetic (PK) study of abiraterone acetate (AA) plus prednisone (P) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Abiraterone acetate; Medicine; Prostate cancer; QT interval; Docetaxel; Pharmacokinetics; Internal medicine; Prednisone; Pharmacology; Cancer; Androgen deprivation therapy; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008714902,0.001029644,0.001663749,0.000337471,0.0004347617,0.0006741417,0.000592101,0.0007432079,0.003877641],"category_scores_gemma":[0.001351978,0.0005577477,0.001092582,0.0004714873,0.0008177929,0.0009038015,0.0003484124,0.002717473,0.0008157141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007094442,"about_ca_system_score_gemma":0.001089872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009835135,"about_ca_topic_score_gemma":0.001753972,"domain_scores_codex":[0.9995279,0.0002257408,0.00003356041,0.00009241563,0.00007196686,0.00004835655],"domain_scores_gemma":[0.9992061,0.0001271313,0.0001833978,0.00007607802,0.00004379861,0.0003634374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8081913,0.04673549,0.008589542,0.0005899664,0.001135498,0.0003869378,0.0003284901,0.001837639,0.07646264,0.0001435902,0.001439609,0.05415927],"study_design_scores_gemma":[0.2986933,0.6579803,0.03199629,0.00002083885,0.0006841784,0.0005647996,0.00006722809,0.001557617,0.005748737,0.0001710771,0.002465001,0.00005063341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955992,0.0009396636,0.0005704866,0.0001609848,0.00005949309,0.00105947,0.0007125964,0.00006408299,0.0008341463],"genre_scores_gemma":[0.9955996,0.0006152628,0.0009375371,0.0001986443,0.0001293669,0.000688349,0.0007331326,0.00001758581,0.001080405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003877641,"threshold_uncertainty_score":0.012972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07343865574434846,"score_gpt":0.3474244786887221,"score_spread":0.2739858229443737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}