{"id":"W2006901432","doi":"10.1210/en.2014-1055","title":"Pseudomonas Aeruginosa Elastase Disrupts the Cortisol-Binding Activity of Corticosteroid-Binding Globulin","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Proteases; Protease; Serpin; Serine protease; Elastase; Neutrophil elastase; Transcortin; Biology; Pseudomonas aeruginosa; Secretion; Biochemistry; Binding protein; Chemistry; Enzyme; Globulin; Inflammation; Endocrinology; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457222,0.0004278998,0.0002420405,0.0001741007,0.00009450505,0.000287716,0.0001955154,0.0002483759,0.0004745441],"category_scores_gemma":[0.0002245103,0.0001292114,0.0002191798,0.0001377203,0.0001937312,0.0001594167,0.0002066235,0.0004509333,0.0002036841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002513634,"about_ca_system_score_gemma":0.0002234172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213567,"about_ca_topic_score_gemma":0.001043614,"domain_scores_codex":[0.9997001,0.00005930882,0.00002882443,0.00003746252,0.00008329379,0.00009105331],"domain_scores_gemma":[0.9997922,0.0000647055,0.00006715967,0.00002505812,0.0000194778,0.0000315139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002777644,0.00001817334,0.00007256625,0.000006856613,0.000001604366,0.00001970317,0.000003710804,0.00001379742,0.9995968,0.000008202857,0.000004992647,0.0002258787],"study_design_scores_gemma":[0.000005189802,0.0002365536,0.004843182,0.0000032593,0.00000615012,0.0001390666,0.00001837621,0.0004063193,0.9939111,0.00001740334,0.0004104965,0.000002845587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970539,0.0006952559,0.001465501,0.00008844076,0.00001740761,0.00002005271,0.0001758908,0.00003460485,0.0004490194],"genre_scores_gemma":[0.9970875,0.000305498,0.001161057,0.00004888103,0.000006519179,0.00001605926,0.0002384354,0.00001457937,0.001121499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213567,"threshold_uncertainty_score":0.002412975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03095701251985269,"score_gpt":0.2906219495939069,"score_spread":0.2596649370740542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}