{"id":"W2006914006","doi":"10.1523/jneurosci.3257-10.2011","title":"Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Sumitomo Foundation; Takeda Science Foundation","keywords":"CREB; Memory consolidation; Downregulation and upregulation; Long-term potentiation; Transgene; Genetically modified mouse; Hippocampus; Neuroscience; Neuronal memory allocation; Brain-derived neurotrophic factor; Psychology; Neurotrophic factors; Biology; Cell biology; Transcription factor; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475856,0.0004146702,0.0003349262,0.0002892929,0.00008367226,0.0002424701,0.0003289507,0.0003325726,0.001193602],"category_scores_gemma":[0.0001548376,0.0001533695,0.0003911395,0.0001116831,0.0002983891,0.0002983556,0.0003040209,0.0006970416,0.0002976283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937205,"about_ca_system_score_gemma":0.0001763371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003536899,"about_ca_topic_score_gemma":0.0007271813,"domain_scores_codex":[0.999868,0.000009977374,0.00001020378,0.00002430768,0.00003769086,0.00004975916],"domain_scores_gemma":[0.9998166,0.0000211575,0.00005324736,0.00002217406,0.00002023302,0.00006660385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000712762,0.00003219998,0.00009719584,0.00002617033,0.000004327528,0.00002777289,0.000005772681,0.00002313562,0.9981537,0.00003965749,0.00001388674,0.001504863],"study_design_scores_gemma":[0.00005422317,0.001184276,0.01567274,0.00001593672,0.00005000806,0.0003037156,0.00002285526,0.0008621304,0.9802204,0.0001689035,0.001434873,0.000009887654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946684,0.00144692,0.002436819,0.00009634607,0.00002849609,0.00001404777,0.0001285052,0.0001339986,0.001046374],"genre_scores_gemma":[0.9947118,0.0009669703,0.002068756,0.00005506915,0.00002330534,0.00002740473,0.0002586481,0.00002460882,0.001863441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193602,"threshold_uncertainty_score":0.003993034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1188049215687367,"score_gpt":0.3507987130743281,"score_spread":0.2319937915055914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}