{"id":"W2006920169","doi":"10.1016/j.molcel.2012.03.026","title":"Molecular Model of the Human 26S Proteasome","year":2012,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Cancer Research UK","keywords":"Biology; Proteasome; Computational biology; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002409704,0.0002095977,0.0001599235,0.00003205824,0.00009195053,0.00001225076,0.0004414246,0.0001813315,0.00002336918],"category_scores_gemma":[0.00003275201,0.0001692165,0.0002487002,0.0001089964,0.0001123244,0.000004730116,0.0002913972,0.0001492185,0.0000158455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000117972,"about_ca_system_score_gemma":0.00006143599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008620385,"about_ca_topic_score_gemma":8.461178e-7,"domain_scores_codex":[0.9986975,0.0001259813,0.0002342379,0.0002643722,0.0002593848,0.0004185083],"domain_scores_gemma":[0.9988772,0.000002715856,0.0001358035,0.0007866538,0.00006982673,0.000127758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008536535,0.0001285431,0.001091983,0.00004798968,0.00002275267,0.000001289524,0.00006724365,0.0006643532,0.9960635,0.001567938,0.0001941273,0.0001417241],"study_design_scores_gemma":[0.0003407969,0.00006920068,0.0001408868,0.00001264333,0.00002929879,0.000004111738,0.00001525951,0.00019178,0.9946591,0.0004044349,0.003916678,0.0002158046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692168,0.001379221,0.005874292,0.00007125274,0.00008349882,0.0005159861,0.00002164391,0.0000142322,0.02282306],"genre_scores_gemma":[0.9972664,0.000008286491,0.001161284,0.0004755507,0.00007284259,0.00006875384,0.00002947468,0.00004891562,0.0008685686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02804951,"threshold_uncertainty_score":0.6900451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456533195508999,"score_gpt":0.2324761102113889,"score_spread":0.2179107782562989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}