{"id":"W2007003497","doi":"10.1074/jbc.m205455200","title":"Metal Ions, pH, and Cholesterol Regulate the Interactions of Alzheimer's Disease Amyloid-β Peptide with Membrane Lipid","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Park","funders":"National Health and Medical Research Council; Medical Research Council; National Institute on Aging; National Institutes of Health","keywords":"Membrane; Lipid bilayer; Chemistry; Peptide; Crystallography; Bilayer; Electron paramagnetic resonance; Cholesterol; Biophysics; Biochemistry; Nuclear magnetic resonance; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461301,0.0002185855,0.0002585176,0.0002140748,0.0001961671,0.0005118662,0.0001432898,0.0002955905,0.0006509934],"category_scores_gemma":[0.0003685129,0.0001746434,0.0001457711,0.0001092887,0.000261923,0.0003061614,0.000312804,0.0002349879,0.0002497492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003502607,"about_ca_system_score_gemma":0.0001806283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008981289,"about_ca_topic_score_gemma":0.0008395815,"domain_scores_codex":[0.9998509,0.00003822436,0.00001238093,0.00001844783,0.00002805543,0.00005201989],"domain_scores_gemma":[0.9998108,0.00003571744,0.00004392779,0.00000790442,0.00004787696,0.00005371398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001276808,0.0000778188,0.003069148,0.00006939821,0.00001788476,0.00020157,0.0001187122,0.00008321244,0.9917458,0.0001163889,0.0001045409,0.003118729],"study_design_scores_gemma":[0.000145271,0.0007488631,0.09751339,0.00003028773,0.00009280585,0.000836454,0.0005261722,0.00328609,0.8927488,0.0006112413,0.003423568,0.00003703184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968607,0.001701401,0.0002992931,0.00005784234,0.00001412208,0.0000144072,0.00004444032,0.00001398882,0.0009936591],"genre_scores_gemma":[0.997995,0.0008180673,0.000403969,0.00004387659,0.000009879281,0.00001500718,0.00004267416,0.000005507591,0.0006660641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008981289,"threshold_uncertainty_score":0.002541363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03351936001786465,"score_gpt":0.3008723409340953,"score_spread":0.2673529809162307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}