{"id":"W2007010482","doi":"10.1159/000330206","title":"Outcomes of Patients with Metastatic Melanoma Treated with Molecularly Targeted Agents in Phase I Clinical Trials","year":2011,"lang":"en","type":"article","venue":"Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Dacarbazine; Internal medicine; Clinical trial; Chemotherapy; Temozolomide; Phases of clinical research; Oncology; Melanoma; Cytokine; Gastroenterology; Surgery; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004506923,0.0003445855,0.001115939,0.0003227065,0.0005212856,0.0009021329,0.000261533,0.0006319733,0.00134736],"category_scores_gemma":[0.005824784,0.0001510203,0.000937918,0.0004484101,0.0003455573,0.0006157659,0.0003830083,0.0008447063,0.0002464997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004260078,"about_ca_system_score_gemma":0.0004540759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001501138,"about_ca_topic_score_gemma":0.000161623,"domain_scores_codex":[0.9981955,0.001069859,0.0002408314,0.0001913889,0.0001619357,0.0001405476],"domain_scores_gemma":[0.9944655,0.001571501,0.002554174,0.000254647,0.0003826008,0.0007716041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1155395,0.003421606,0.8061718,0.0007350143,0.002289542,0.0007060152,0.0002690837,0.002248657,0.007024399,0.0002786845,0.002664101,0.05865156],"study_design_scores_gemma":[0.0304654,0.1617616,0.7820712,0.0002534698,0.002969583,0.003456774,0.0002473343,0.003259495,0.007145219,0.00091229,0.007386322,0.00007125437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925648,0.004048449,0.0004864603,0.0002572082,0.00003586338,0.0003631799,0.0008044559,0.00001625733,0.001423286],"genre_scores_gemma":[0.9954168,0.0007370429,0.0004073551,0.0002797703,0.00008334572,0.0004818715,0.00225601,0.000006247669,0.0003316692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004506923,"threshold_uncertainty_score":0.02383512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1193280521944328,"score_gpt":0.3919691157399389,"score_spread":0.2726410635455062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}