{"id":"W2007010482","doi":"10.1159/000330206","title":"Outcomes of Patients with Metastatic Melanoma Treated with Molecularly Targeted Agents in Phase I Clinical Trials","year":2011,"lang":"en","type":"article","venue":"Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Dacarbazine; Internal medicine; Clinical trial; Chemotherapy; Temozolomide; Phases of clinical research; Oncology; Melanoma; Cytokine; Gastroenterology; Surgery; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00085155,0.0001986649,0.0008439607,0.00008951762,0.00001929918,0.000003350937,0.0001734262,0.0001836899,0.0001149758],"category_scores_gemma":[0.0003347211,0.0001282185,0.0001164025,0.0001159252,0.0001404395,0.000005031687,0.00004701164,0.0001045071,0.000006811124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001653,"about_ca_system_score_gemma":0.0001724363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008143147,"about_ca_topic_score_gemma":0.0001687942,"domain_scores_codex":[0.9976215,0.0008682701,0.000767172,0.0003626738,0.0001271821,0.0002531451],"domain_scores_gemma":[0.9988937,0.00008439422,0.0004503678,0.0003344687,0.0001226857,0.0001143618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005009899,0.004184876,0.9720202,0.00001639632,0.0006282391,0.0001384237,0.0001185186,0.000001611642,0.01151892,0.00006703218,0.0002224894,0.006073366],"study_design_scores_gemma":[0.03176859,0.03495655,0.8602929,0.00001711382,0.0003704421,0.000009934666,0.00009265341,0.00001698719,0.06809851,0.00004339739,0.003967458,0.0003655216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966175,0.0000563317,0.0007679357,0.0000135157,0.00008327942,0.0005587683,0.00007879436,0.000007722888,0.001816159],"genre_scores_gemma":[0.995566,0.00001530013,0.003691997,0.0001644746,0.00001890543,0.0000573666,0.0003371976,0.00002419204,0.0001245584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1117274,"threshold_uncertainty_score":0.5228597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1193280521944328,"score_gpt":0.3919691157399389,"score_spread":0.2726410635455062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}