{"id":"W2007010532","doi":"10.1074/jbc.m113.523183","title":"Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Histone H3; Histone methyltransferase; Histone; Histone methylation; Histone H2A; Chemistry; Cell biology; Biology; Biochemistry; Genetics; Molecular biology; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007702477,0.000159855,0.0003252678,0.0000273652,0.00004840595,0.000009712579,0.0002127057,0.0003185433,0.00006568906],"category_scores_gemma":[0.0003394904,0.0001224166,0.0002054904,0.00008768291,0.0001274377,0.000004498891,0.00003360752,0.0001820077,7.830855e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002046774,"about_ca_system_score_gemma":0.00003932848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004928068,"about_ca_topic_score_gemma":4.338675e-7,"domain_scores_codex":[0.9986795,0.0001242446,0.0006408363,0.0002037426,0.0001906098,0.0001610448],"domain_scores_gemma":[0.9989144,0.00003282961,0.0004813619,0.000204517,0.0002521554,0.0001146955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001639223,0.0001598185,0.0007509555,0.00003570448,0.0000423354,9.095395e-7,0.000007692613,0.00002362096,0.9962018,0.00001106506,0.0001461018,0.002456055],"study_design_scores_gemma":[0.0007609507,0.0007940701,0.001044379,0.00002086232,0.00002666864,0.000005346222,0.000009995294,0.00001216659,0.9867577,0.0005043871,0.009920523,0.0001429641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860129,0.002301402,0.01053015,0.00009389073,0.00003709817,0.00008884037,0.00001324346,0.000004377265,0.0009180531],"genre_scores_gemma":[0.9976873,0.0001583051,0.001420508,0.00002534291,0.0002982596,0.000003444493,0.0001020276,0.00001195791,0.0002928122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01167439,"threshold_uncertainty_score":0.4992005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606900841776212,"score_gpt":0.2993970241098113,"score_spread":0.2833280156920492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}