{"id":"W2007037292","doi":"10.3816/cbc.2009.n.044","title":"TRIO-012: A Multicenter, Multinational, Randomized, Double-Blind Phase III Study of IMC-1121B Plus Docetaxel Versus Placebo Plus Docetaxel in Previously Untreated Patients With HER2-Negative, Unresectable, Locally Recurrent or Metastatic Breast Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of Alberta","funders":"","keywords":"Docetaxel; Medicine; Metastatic breast cancer; Ramucirumab; Placebo; Internal medicine; Oncology; Chemotherapy; Randomized controlled trial; Breast cancer; Phases of clinical research; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002389866,0.002708145,0.003898252,0.0008484918,0.00075935,0.001492643,0.00166512,0.00222036,0.006939007],"category_scores_gemma":[0.001566984,0.001287309,0.001584042,0.0008418346,0.002081698,0.001517033,0.0004980469,0.005803217,0.001781931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001025596,"about_ca_system_score_gemma":0.002351221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001994464,"about_ca_topic_score_gemma":0.005544864,"domain_scores_codex":[0.9993867,0.0003270421,0.00002663185,0.00009776798,0.00004386609,0.0001179317],"domain_scores_gemma":[0.9991159,0.00016439,0.0001757395,0.00006645752,0.00004973828,0.0004277034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9403726,0.02620127,0.0007639128,0.0006352828,0.0009706594,0.00004449878,0.0001107147,0.0007378211,0.00647918,0.0002276866,0.002181647,0.02127456],"study_design_scores_gemma":[0.9291288,0.06824402,0.0008888242,0.00001598344,0.0002734862,0.00003157248,0.00002554806,0.0003403136,0.0004453134,0.00007327714,0.0005153041,0.00001754939],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821895,0.00411703,0.001129945,0.001276028,0.0006967223,0.004894011,0.002075539,0.0004558155,0.003165292],"genre_scores_gemma":[0.9695013,0.004887424,0.003139742,0.002289953,0.0005868999,0.007812873,0.002976337,0.0001321291,0.008673413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006939007,"threshold_uncertainty_score":0.02321327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07878283885101223,"score_gpt":0.4425120655689957,"score_spread":0.3637292267179835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}