{"id":"W2007037292","doi":"10.3816/cbc.2009.n.044","title":"TRIO-012: A Multicenter, Multinational, Randomized, Double-Blind Phase III Study of IMC-1121B Plus Docetaxel Versus Placebo Plus Docetaxel in Previously Untreated Patients With HER2-Negative, Unresectable, Locally Recurrent or Metastatic Breast Cancer","year":2009,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of Alberta","funders":"","keywords":"Docetaxel; Medicine; Metastatic breast cancer; Ramucirumab; Placebo; Internal medicine; Oncology; Chemotherapy; Randomized controlled trial; Breast cancer; Phases of clinical research; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009535906,0.0008257023,0.003181851,0.0004202545,0.000135146,0.00004676144,0.0003647307,0.0002283078,0.002270751],"category_scores_gemma":[0.0002682881,0.0005492329,0.0004267952,0.00122015,0.0005439071,0.0003322676,0.0001034564,0.0008789704,0.00001196065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001540087,"about_ca_system_score_gemma":0.002218718,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01010368,"about_ca_topic_score_gemma":0.01748261,"domain_scores_codex":[0.9934639,0.0009042693,0.00246237,0.001245103,0.001027206,0.0008971879],"domain_scores_gemma":[0.994126,0.002169764,0.001262823,0.0005416812,0.001275108,0.0006246158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8934966,0.03750375,0.02680206,0.0001855763,0.003210516,0.0001613949,0.001450427,0.001056346,0.000006030092,0.000004814436,0.0006825153,0.03544003],"study_design_scores_gemma":[0.894841,0.007388646,0.08702704,0.001029674,0.00452749,0.00002879935,0.0004805139,0.004021514,0.00002333801,0.000004622636,0.0001121936,0.0005152138],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817052,0.001133746,0.00003055452,0.001619693,0.0009435415,0.01310793,0.001230806,0.00007752859,0.0001509313],"genre_scores_gemma":[0.9941907,0.001561463,0.0001932922,0.0004867842,0.0003436052,0.002143948,0.0003065005,0.00007450057,0.0006991859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06022498,"threshold_uncertainty_score":0.9996959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07878283885101223,"score_gpt":0.4425120655689957,"score_spread":0.3637292267179835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}