{"id":"W2007086609","doi":"10.1186/1471-2407-14-328","title":"YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells","year":2014,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta; Translational Research in Oncology","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"SOX2; Gene knockdown; Chromatin immunoprecipitation; Cancer research; Transcription factor; Cyclin D1; Reporter gene; Biology; Molecular biology; Cancer stem cell; Cancer cell; Stem cell; Cell culture; Chemistry; Gene expression; Cell; Promoter; Cell biology; Cancer; Gene; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117495,0.0002916747,0.0002512138,0.00025025,0.0001995934,0.0003102136,0.0001522222,0.0001372828,0.0009406019],"category_scores_gemma":[0.00008202869,0.000119769,0.0002034161,0.0001936763,0.0001870114,0.0001086736,0.0002200946,0.0003422347,0.0004169329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003517741,"about_ca_system_score_gemma":0.0002587191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262994,"about_ca_topic_score_gemma":0.002179803,"domain_scores_codex":[0.9998742,0.000009504868,0.00001021346,0.00002829466,0.00004509735,0.00003265522],"domain_scores_gemma":[0.9998938,0.000008340249,0.00003631678,0.00001021348,0.00002149339,0.00002978299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003282482,0.000005345169,0.0003720707,0.00001592152,0.000002519095,0.0000298935,0.00001079833,0.00001367343,0.9990469,0.0000241217,0.00003615669,0.0004098668],"study_design_scores_gemma":[0.00001435535,0.00007696306,0.03438534,0.000006828906,0.00002233659,0.0003795053,0.00006219513,0.000975886,0.9604142,0.0000291319,0.003628153,0.000005142831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938318,0.002289121,0.002109394,0.00008844236,0.00002563837,0.00001700576,0.0005620429,0.00008308416,0.0009935116],"genre_scores_gemma":[0.9938983,0.000735465,0.001294526,0.00004610363,0.00001304872,0.00002895949,0.001249525,0.00002875488,0.00270531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262994,"threshold_uncertainty_score":0.003146589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982221482420468,"score_gpt":0.2659489770677931,"score_spread":0.2461267622435884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}