{"id":"W2007086609","doi":"10.1186/1471-2407-14-328","title":"YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells","year":2014,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta; Translational Research in Oncology","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"SOX2; Gene knockdown; Chromatin immunoprecipitation; Cancer research; Transcription factor; Cyclin D1; Reporter gene; Biology; Molecular biology; Cancer stem cell; Cancer cell; Stem cell; Cell culture; Chemistry; Gene expression; Cell; Promoter; Cell biology; Cancer; Gene; Cell cycle; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002916844,0.0002257004,0.0005968328,0.0001348074,0.00004272993,0.00002427756,0.0001098351,0.00006874538,0.000322074],"category_scores_gemma":[0.00004160204,0.0001728544,0.00007846813,0.0003443295,0.0001359911,0.00006942516,0.00008398831,0.0001258199,0.000004040035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317438,"about_ca_system_score_gemma":0.0004192752,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01124244,"about_ca_topic_score_gemma":0.01737098,"domain_scores_codex":[0.9984596,0.00007079222,0.0003960423,0.0004159197,0.0002635412,0.0003940777],"domain_scores_gemma":[0.9990866,0.00004923686,0.0001180127,0.0003116187,0.0002200498,0.0002144718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01068821,0.000795569,0.5634829,0.008245293,0.0003005059,0.00009212364,0.003827989,0.001542407,0.2498271,0.0007674377,0.006383423,0.1540471],"study_design_scores_gemma":[0.005414683,0.0003466099,0.8479008,0.00191842,0.0003617024,0.00009189295,0.0007570111,0.0006122041,0.1204656,0.0001252331,0.02134164,0.0006642134],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944588,0.002851285,0.0002398435,0.0009531045,0.0002355183,0.000705725,0.0001590033,0.00002666599,0.0003700451],"genre_scores_gemma":[0.9960244,0.0001926835,0.0002451949,0.0002068287,0.0002528325,0.0002357487,0.000006746858,0.00004021614,0.002795376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2844179,"threshold_uncertainty_score":0.9953418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982221482420468,"score_gpt":0.2659489770677931,"score_spread":0.2461267622435884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}