{"id":"W2007103825","doi":"10.1016/j.bmcl.2008.01.122","title":"Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Chemistry; Inhibitory postsynaptic potential; Thrombin; Stereochemistry; Core (optical fiber); Discovery and development of direct thrombin inhibitors; Structure–activity relationship; Combinatorial chemistry; In vitro; Biochemistry; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161655,0.0003074859,0.0001613774,0.0001320982,0.0001555185,0.0003211017,0.0003717965,0.0002532976,0.0010368],"category_scores_gemma":[0.000168989,0.000173428,0.0001691607,0.000142132,0.0001234352,0.0002755808,0.0002280977,0.0003968106,0.0003607002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376636,"about_ca_system_score_gemma":0.0002338253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002733584,"about_ca_topic_score_gemma":0.0003545857,"domain_scores_codex":[0.9999305,0.00001713432,0.000006156148,0.0000138371,0.00001098876,0.00002131636],"domain_scores_gemma":[0.9999511,0.000008320421,0.0000135473,0.00000609889,0.00000705984,0.00001381149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006691,0.0001626626,0.0002489698,0.0002681121,0.00001436056,0.0004036614,0.00009173204,0.002818712,0.9626952,0.002677136,0.0004417582,0.02917107],"study_design_scores_gemma":[0.0001094388,0.00138052,0.0005190164,0.00001094313,0.0000161286,0.0003507365,0.00001473876,0.003466429,0.9888292,0.0003084433,0.00497761,0.00001682108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799818,0.00228102,0.01119122,0.0001116232,0.00004204707,0.0001730811,0.0002748756,0.0001209779,0.005823368],"genre_scores_gemma":[0.9861168,0.001039194,0.01008122,0.00006926257,0.00001029312,0.00009059502,0.0002370214,0.00002234616,0.002333239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010368,"threshold_uncertainty_score":0.003468394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04539560148667861,"score_gpt":0.2562850127899416,"score_spread":0.210889411303263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}