{"id":"W2007120217","doi":"10.1016/j.bbamcr.2014.06.018","title":"Regulation of methylglyoxal-elicited leukocyte recruitment by endothelial SGK1/GSK3 signaling","year":2014,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Calgary","keywords":"SGK1; Cell biology; CREB; Biology; Protein kinase B; Signal transduction; Gene silencing; Kinase; PI3K/AKT/mTOR pathway; Wortmannin; Downregulation and upregulation; Endothelial stem cell; GSK-3; Small interfering RNA; Phosphorylation; Cell adhesion molecule; GSK3B; Transcription factor; Biochemistry; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002078778,0.0003957562,0.0004073358,0.0003610083,0.0002334497,0.0000864342,0.0008936159,0.0003133423,0.00004704369],"category_scores_gemma":[0.0006447645,0.0003960977,0.0002406833,0.0008767578,0.0004795031,0.00002438245,0.00052886,0.0005830593,0.00004840925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009586821,"about_ca_system_score_gemma":0.0002606569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006421693,"about_ca_topic_score_gemma":0.000002158655,"domain_scores_codex":[0.9942242,0.001628697,0.0006141784,0.001197192,0.0014214,0.0009143522],"domain_scores_gemma":[0.9968951,0.0002095149,0.0002758444,0.001449403,0.0008759757,0.0002941815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004170062,0.0002937788,0.000001939577,0.0001049058,0.00009242994,0.000001787085,0.000110388,0.0001681321,0.9932957,0.000269672,0.00262328,0.002620992],"study_design_scores_gemma":[0.0009705071,0.0008367642,0.00006276427,0.00003690025,0.00002337044,0.000002260392,0.00005689575,0.0003430747,0.9649706,0.0005495536,0.03177214,0.0003751423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873739,0.0005126969,0.006589338,0.00158058,0.00008846993,0.001274689,0.00008836515,0.00003827437,0.002453655],"genre_scores_gemma":[0.9926544,0.0005211924,0.003608345,0.0002581448,0.0002604659,0.0001791662,0.0008744426,0.0001191461,0.001524724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02914886,"threshold_uncertainty_score":0.9998491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04962347740573338,"score_gpt":0.3574519896553094,"score_spread":0.307828512249576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}