{"id":"W2007121264","doi":"10.1089/nat.2011.0286","title":"Structural Diversity Repertoire of Gene Silencing Small Interfering RNAs","year":2011,"lang":"en","type":"review","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"PCL Construction (Canada)","funders":"","keywords":"RNA interference; Gene silencing; Trans-acting siRNA; Small interfering RNA; RNA silencing; Biology; RNA-induced silencing complex; Cell biology; Gene; Computational biology; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001164666,0.0004342034,0.0008180275,0.00008591788,0.0001370101,0.00001819921,0.0008321168,0.0005260956,0.00005959601],"category_scores_gemma":[0.00001160254,0.0003687573,0.0005513583,0.00008399114,0.0001281849,0.000005113669,0.0007456756,0.0002794443,0.00001841511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004014622,"about_ca_system_score_gemma":0.0001094421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004582672,"about_ca_topic_score_gemma":0.00001899084,"domain_scores_codex":[0.9984922,0.00009496693,0.0004970286,0.0004948536,0.0001148568,0.0003061326],"domain_scores_gemma":[0.998664,0.00001070147,0.000405985,0.0007284186,0.0001209378,0.00006996073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004801945,0.00002814556,0.00005986161,0.00142217,0.0008164564,0.000007097161,0.0003903759,0.000001125489,0.02799477,0.00001991762,0.00003287123,0.9691792],"study_design_scores_gemma":[0.0005190744,0.001120906,0.00006063285,0.003921077,0.002003156,0.000209732,0.0002650718,0.00003791024,0.1189826,0.00008405373,0.8712578,0.001538023],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04791791,0.9505867,0.0002179223,0.000002206353,0.000469691,0.0002173045,0.00005764907,0.0000185011,0.0005121058],"genre_scores_gemma":[0.03864769,0.9602333,0.0003992063,0.00009492056,0.0002279666,0.000006122327,0.0001093762,0.00006399847,0.0002174061],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9676412,"threshold_uncertainty_score":0.9998764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0918651809273033,"score_gpt":0.2898918200729756,"score_spread":0.1980266391456723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}