{"id":"W2007146182","doi":"10.1182/blood-2011-03-345991","title":"The mismatch repair pathway functions normally at a non-AID target in germinal center B cells","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Germinal center; Mutation frequency; Molecular biology; Biology; MSH2; Mutation; Mutagenesis; DNA mismatch repair; Somatic hypermutation; Reporter gene; B cell; Gene; Genetics; Antibody; Gene expression; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388809,0.0003124871,0.0002521004,0.0003873277,0.0001765068,0.000406833,0.0002257545,0.0003358228,0.001378917],"category_scores_gemma":[0.0002248336,0.0001793092,0.0001359233,0.0001936643,0.0002653348,0.0001956542,0.0002547858,0.0004971649,0.0006415512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003372501,"about_ca_system_score_gemma":0.0002494094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007065656,"about_ca_topic_score_gemma":0.0008970097,"domain_scores_codex":[0.9997591,0.0000353479,0.00001722092,0.00006045264,0.0000737643,0.00005408005],"domain_scores_gemma":[0.9997243,0.00003048451,0.00008173179,0.00004202448,0.00002781187,0.00009367905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003174663,0.000006198898,0.0004118725,0.0000113312,0.000002631639,0.00003006238,0.000007731777,0.00002049926,0.998651,0.00007274685,0.00001421199,0.0007399936],"study_design_scores_gemma":[0.000008406239,0.0001544038,0.007748882,0.000003865717,0.000008583227,0.0005778705,0.00002644461,0.0002678468,0.9897064,0.00005566444,0.001439207,0.000002367274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960955,0.0007800827,0.001983516,0.0000450181,0.0000083758,0.000009255265,0.0001284287,0.000118912,0.0008308266],"genre_scores_gemma":[0.9962894,0.000244654,0.001557584,0.00001700994,0.000004344302,0.000008937711,0.0002221929,0.00001905908,0.001636834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378917,"threshold_uncertainty_score":0.004612982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01484315966044994,"score_gpt":0.2160089130755244,"score_spread":0.2011657534150745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}