{"id":"W2007201741","doi":"10.1111/j.1349-7006.2008.00919.x","title":"Conditioned media from mouse osteosarcoma cells promote MC3T3‐E1 cell proliferation using JAKs and PI3‐K/Akt signal crosstalk","year":2008,"lang":"en","type":"article","venue":"Cancer Science","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"National Institutes of Health; National Cancer Institute; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; Cell growth; Cancer research; Crosstalk; Cell biology; MAPK/ERK pathway; Signal transduction; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491425,0.0001510786,0.0002030295,0.0001455426,0.0006218257,0.00009623748,0.0001202917,0.00005680243,0.0004176253],"category_scores_gemma":[0.00004505485,0.0001336034,0.00004399589,0.0003980017,0.0006535557,0.0005072709,0.00005442296,0.0001925775,0.00001576805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747866,"about_ca_system_score_gemma":0.0007512014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005192964,"about_ca_topic_score_gemma":0.00004673791,"domain_scores_codex":[0.9985321,0.00001990312,0.0002492631,0.0004525632,0.0004504925,0.0002956529],"domain_scores_gemma":[0.9990756,0.00004786022,0.0001222235,0.0002204481,0.0002918242,0.0002420687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004660434,0.00006870925,0.002044087,0.00001487092,0.000005586897,0.00002638367,0.002113855,0.0001030852,0.9947766,0.00000962338,0.0002356078,0.0005549554],"study_design_scores_gemma":[0.000874344,0.000158316,0.003311622,0.00008600706,0.00003402452,0.00007147314,0.0001422332,0.01133146,0.983184,0.00003893395,0.0006108,0.0001567453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965521,0.0002922525,0.001724516,0.0001835958,0.0003872119,0.0003561584,0.0001452704,0.00005611799,0.0003027635],"genre_scores_gemma":[0.996612,0.0000493036,0.002340768,0.000327848,0.000335342,0.00002658487,0.00002722875,0.00001574387,0.000265222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01159259,"threshold_uncertainty_score":0.5448189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04275701400557012,"score_gpt":0.2951545340537333,"score_spread":0.2523975200481632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}