{"id":"W2007211948","doi":"10.1074/jbc.m112.418830","title":"The Intermediate Filament Vimentin Mediates MicroRNA miR-378 Function in Cellular Self-renewal by Regulating the Expression of the Sox2 Transcription Factor","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research","keywords":"Vimentin; SOX2; Biology; Transfection; microRNA; Carcinogenesis; Gene silencing; Ectopic expression; Cancer research; Cancer stem cell; Cell; Cell biology; Cell culture; Stem cell; Cancer cell; Molecular biology; Transcription factor; Cancer; Immunology; Genetics; Immunohistochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200867,0.0002987438,0.0001516868,0.0001801812,0.0002116675,0.0002402083,0.0001832773,0.000149289,0.0009401732],"category_scores_gemma":[0.00014763,0.0001290428,0.0002095034,0.00008131808,0.000173308,0.0001929602,0.0001775155,0.0002157043,0.0003965117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141144,"about_ca_system_score_gemma":0.0001824485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005024138,"about_ca_topic_score_gemma":0.0009046083,"domain_scores_codex":[0.9999024,0.00001772945,0.000008120495,0.00002071376,0.00003250024,0.00001853387],"domain_scores_gemma":[0.9999295,0.00001216565,0.00001974883,0.000008022449,0.00001417125,0.00001628484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004410157,0.000004869446,0.0002842559,0.00001894007,0.00000255442,0.00005795709,0.00001295891,0.00004255123,0.9979692,0.0002211036,0.00002542236,0.00131613],"study_design_scores_gemma":[0.000003778038,0.00005196723,0.003011953,0.000003174257,0.000009607197,0.0002406922,0.00001584399,0.0009020614,0.9935243,0.00007334596,0.002160749,0.000002566542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977016,0.00314293,0.01528147,0.0001107919,0.00004641296,0.00002896262,0.0002542931,0.000164255,0.003954979],"genre_scores_gemma":[0.9928746,0.000719874,0.00430856,0.00001788552,0.000006674848,0.00001677562,0.0002256187,0.00001857051,0.001811549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009401732,"threshold_uncertainty_score":0.003145218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354343967065271,"score_gpt":0.2401703315726328,"score_spread":0.2266268919019801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}