{"id":"W2007224179","doi":"10.1021/jp111112s","title":"Modeling Stochastic Dynamics in Biochemical Systems with Feedback Using Maximum Caliber","year":2011,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Bistability; Dynamical systems theory; Computer science; Stochastic modelling; Statistical physics; Control theory (sociology); Mathematics; Physics; Statistics; Artificial intelligence; Control (management)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001831188,0.0007042278,0.0007543323,0.0009145649,0.0005336063,0.0006757305,0.001064725,0.0009893643,0.0007696995],"category_scores_gemma":[0.005846479,0.0005611125,0.0009177086,0.000520363,0.001117128,0.001670769,0.0007923839,0.0009618505,0.00007757116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009561946,"about_ca_system_score_gemma":0.0006336301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003224927,"about_ca_topic_score_gemma":0.002483197,"domain_scores_codex":[0.999633,0.0001632822,0.00001654635,0.00007084855,0.0000767619,0.0000396332],"domain_scores_gemma":[0.9969974,0.002394578,0.0003438681,0.000113233,0.00007212412,0.00007884986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0000237463,0.00001437691,0.0006039064,0.0000154317,0.00001493719,0.00003102189,0.00003187747,0.9830028,0.001903578,0.01196867,0.00006157078,0.002328052],"study_design_scores_gemma":[0.000002451248,0.000004892941,0.00006889689,0.000001148269,0.00000125001,0.000003715384,0.000001023891,0.9954523,0.0001492096,0.004278786,0.00003355413,0.000002669087],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1912575,0.0002541216,0.8066196,0.0002792161,0.00001929605,0.00004246104,0.00009272355,0.0001955571,0.001239619],"genre_scores_gemma":[0.9429493,0.0002558786,0.05555409,0.00005803493,0.00002524289,0.0001403827,0.00009617727,0.00006334925,0.0008574116],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003224927,"threshold_uncertainty_score":0.009684384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01457346545188592,"score_gpt":0.2214514955808646,"score_spread":0.2068780301289787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}