{"id":"W2007242382","doi":"10.1139/o11-063","title":"Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1)","year":2011,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Trace Elements in Health","field":"Nursing","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Transactivation; Chromatin immunoprecipitation; Transcription factor; Biology; Molecular biology; Transcription (linguistics); Cell biology; Hypoxia-inducible factors; Metallothionein; Promoter; Gene; Chemistry; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002546225,0.0002408642,0.0002265717,0.00002890796,0.000253549,0.0000174355,0.000203002,0.0003055037,0.0001226105],"category_scores_gemma":[0.0001058937,0.0001887609,0.0000724804,0.000140726,0.0001149116,0.0001170145,0.00001677732,0.0002852176,0.000008295266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006087125,"about_ca_system_score_gemma":0.00003253715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001102394,"about_ca_topic_score_gemma":0.000007735311,"domain_scores_codex":[0.9984961,0.0002214667,0.0003241617,0.0004701735,0.0001082,0.0003798693],"domain_scores_gemma":[0.9991677,0.0002770087,0.0001352575,0.0002571947,0.00005411059,0.0001086972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005199014,0.0001215295,0.00009627646,0.00005164041,0.00003250239,7.416885e-7,0.005059034,0.000002931104,0.9891835,0.00003026226,0.00008154244,0.004820175],"study_design_scores_gemma":[0.0005598638,0.0002821885,0.0002959896,0.0000156801,0.00004911891,0.000003505366,0.001190461,0.00001642456,0.9900957,0.0002040503,0.007068611,0.0002183988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934152,0.0008285209,0.003804986,0.0004668737,0.0003872275,0.0004126107,0.0001870834,0.00006810146,0.0004293612],"genre_scores_gemma":[0.9977303,0.00003258056,0.00120891,0.0006874868,0.0000795683,0.00005203561,0.0000973622,0.00002328412,0.00008846348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006987068,"threshold_uncertainty_score":0.7697448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0569715385468649,"score_gpt":0.2677698169490127,"score_spread":0.2107982784021478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}