{"id":"W2007244362","doi":"10.1128/mcb.01868-08","title":"Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence","year":2009,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":389,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Biology; Senescence; Cell biology; Mitochondrion; Mitochondrial DNA; DNA damage; Cell cycle; Reactive oxygen species; Oxidative phosphorylation; Mitochondrial ROS; DNAJA3; Oxidative stress; Cell cycle checkpoint; Cell; mitochondrial fusion; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009966725,0.0002020307,0.0003624832,0.0001460366,0.00009098775,0.00001922295,0.00008362932,0.0002211839,0.00002671363],"category_scores_gemma":[0.0001119253,0.0001761673,0.00009330097,0.0002431102,0.00005886846,0.00002311226,0.00003103369,0.0001520378,0.0000434187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003507439,"about_ca_system_score_gemma":0.00006066006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004385304,"about_ca_topic_score_gemma":0.000005708431,"domain_scores_codex":[0.9987411,0.00008305241,0.0002417601,0.0004655035,0.0001054513,0.0003630883],"domain_scores_gemma":[0.9993057,0.00002264863,0.00004571288,0.0003027859,0.00009790729,0.0002252106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002911023,0.00007558558,0.001193944,0.00001043006,0.0000335601,0.0001408974,0.00005307696,6.759e-7,0.9678162,0.001080478,0.0001663547,0.02913767],"study_design_scores_gemma":[0.001707577,0.001294844,0.004195096,0.00003952068,0.00008922305,0.00008853101,0.00005015947,0.00005216839,0.9784565,0.0005287268,0.01326516,0.0002325216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553389,0.001553991,0.03898092,0.002661106,0.0004867218,0.0004241607,0.000005176158,0.00007236801,0.0004766515],"genre_scores_gemma":[0.9945946,0.00004468228,0.0007937407,0.004094065,0.0001932693,0.00001084191,0.00006818544,0.00001294956,0.0001876607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0392557,"threshold_uncertainty_score":0.7183893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045601846445085,"score_gpt":0.2590224542898978,"score_spread":0.2485664358254469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}