{"id":"W2007244362","doi":"10.1128/mcb.01868-08","title":"Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence","year":2009,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":389,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Biology; Senescence; Cell biology; Mitochondrion; Mitochondrial DNA; DNA damage; Cell cycle; Reactive oxygen species; Oxidative phosphorylation; Mitochondrial ROS; DNAJA3; Oxidative stress; Cell cycle checkpoint; Cell; mitochondrial fusion; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510714,0.0002640303,0.0001892641,0.0003435133,0.0001893791,0.0003954587,0.0001137328,0.0003378005,0.0007257454],"category_scores_gemma":[0.0002898691,0.0000997245,0.0001772665,0.0001500812,0.0002062531,0.0002406158,0.0003130393,0.0003815683,0.0002131036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240287,"about_ca_system_score_gemma":0.0001492099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001103223,"about_ca_topic_score_gemma":0.0001427996,"domain_scores_codex":[0.9999133,0.00002126284,0.00001054464,0.00001266123,0.00001988544,0.00002237385],"domain_scores_gemma":[0.9997631,0.00003529158,0.0001021476,0.0000281069,0.00002753575,0.00004387722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006208163,0.0001014602,0.008237741,0.0002020147,0.00003276629,0.001561685,0.0001273331,0.0003061618,0.9720366,0.001788387,0.0002694977,0.01471544],"study_design_scores_gemma":[0.0001122655,0.002179447,0.1202869,0.0001167617,0.0001861226,0.02022906,0.0003599136,0.005412381,0.8186841,0.007295233,0.02510579,0.00003206361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797885,0.0154583,0.002236645,0.0004748538,0.000050796,0.00001454709,0.00007897839,0.00007550796,0.001821843],"genre_scores_gemma":[0.9955631,0.003629362,0.0002480144,0.00003303288,0.00002010393,0.000003680839,0.00005146484,0.000002514834,0.0004487895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007257454,"threshold_uncertainty_score":0.002427876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045601846445085,"score_gpt":0.2590224542898978,"score_spread":0.2485664358254469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}