{"id":"W2007265480","doi":"10.1503/cmaj.1060140","title":"Fundamental problem with opioid trials for chronic pain","year":2007,"lang":"en","type":"letter","venue":"Canadian Medical Association Journal","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Placebo; Opioid; Medicine; Chronic pain; Clinical trial; Anesthesia; Computer science; Alternative medicine; Physical therapy; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1375676,0.001208379,0.003606443,0.001964587,0.003552934,0.005201592,0.004316397,0.04558899,0.008240192],"category_scores_gemma":[0.3675593,0.001275093,0.002605148,0.002474817,0.01240728,0.01092015,0.003103884,0.05066185,0.009084535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005480319,"about_ca_system_score_gemma":0.005431545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270936,"about_ca_topic_score_gemma":0.002391631,"domain_scores_codex":[0.846862,0.09834904,0.01468925,0.00648644,0.03247756,0.001135645],"domain_scores_gemma":[0.4950902,0.453419,0.01114622,0.01010102,0.02448506,0.005758573],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001149029,0.0001341216,0.0008398437,0.001847797,0.0002256287,0.000808902,0.0004365561,0.000282124,0.0004685646,0.03598255,0.8284251,0.1293998],"study_design_scores_gemma":[0.002235684,0.0008819498,0.001449855,0.003536289,0.0001562101,0.002509997,0.0003330665,0.001120797,0.0004012774,0.127237,0.8600015,0.0001363369],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000253598,0.008933153,0.001283543,0.9676635,0.01912368,0.00005604626,0.00006154251,0.0000533544,0.002571499],"genre_scores_gemma":[0.006054191,0.005099122,0.00501135,0.8815029,0.1004494,0.000349452,0.00004216737,0.00004843373,0.001442914],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.8624324,"threshold_uncertainty_score":0.7275357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03682776585104136,"score_gpt":0.2828383528971866,"score_spread":0.2460105870461452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}