{"id":"W2007265480","doi":"10.1503/cmaj.1060140","title":"Fundamental problem with opioid trials for chronic pain","year":2007,"lang":"en","type":"letter","venue":"Canadian Medical Association Journal","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Placebo; Opioid; Medicine; Chronic pain; Clinical trial; Anesthesia; Computer science; Alternative medicine; Physical therapy; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","research_integrity"],"category_scores_codex":[0.05019689,0.00031991,0.0006708676,0.0006713821,0.0006121648,0.0006139015,0.0005927733,0.001310082,0.003544746],"category_scores_gemma":[0.02311636,0.0002629477,0.0003093413,0.0003250806,0.00008091849,0.0001398584,0.00001711189,0.003423937,0.0001528493],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004542765,"about_ca_system_score_gemma":0.005432954,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097506,"about_ca_topic_score_gemma":0.02071189,"domain_scores_codex":[0.9898023,0.005246567,0.0008310889,0.0004195295,0.002455996,0.001244547],"domain_scores_gemma":[0.985343,0.01251323,0.0009634544,0.0001443742,0.000142718,0.0008932142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001901226,0.000006873097,0.0002415548,0.00009398051,0.0000945509,0.001202621,0.00003599267,0.000002260871,0.00001644071,0.00002043208,0.9569975,0.04126881],"study_design_scores_gemma":[0.00134753,0.0002553108,0.00002299904,0.0002547982,0.00008517066,0.0001019871,0.0000144625,0.0004651733,0.0000334982,0.0001664633,0.9969264,0.0003262284],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0000862526,0.0001964213,0.009339252,0.9804946,0.002162395,0.001923307,0.000282421,0.0000566216,0.0054588],"genre_scores_gemma":[0.0003259591,0.0001413416,0.0002155605,0.9654887,0.0238949,0.00009687446,0.0001421515,0.00006702962,0.009627505],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04094259,"threshold_uncertainty_score":0.9999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03682776585104136,"score_gpt":0.2828383528971866,"score_spread":0.2460105870461452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}