{"id":"W2007293173","doi":"10.3109/10837450.2012.680598","title":"New immediate release formulation for deterring abuse of methadone","year":2012,"lang":"en","type":"article","venue":"Pharmaceutical Development and Technology","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paladin Labs (Canada)","funders":"","keywords":"Methadone; Immediate release; Abuse liability; Pharmacology; Drug; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002310796,0.0001023778,0.0001954352,0.0002605412,0.00004173506,0.000003247451,0.00005111458,0.00009866223,0.00002231744],"category_scores_gemma":[0.00008737486,0.0000893019,0.00002610215,0.0001989999,0.00002922624,0.00008044903,0.00004945714,0.0001023117,0.000008388473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002595732,"about_ca_system_score_gemma":0.00003126542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001044944,"about_ca_topic_score_gemma":5.438514e-7,"domain_scores_codex":[0.9992364,0.000006367874,0.0002342875,0.0001274171,0.00009625168,0.0002992572],"domain_scores_gemma":[0.9996025,0.00006275583,0.00005148605,0.00009021982,0.00003822665,0.0001548355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003778004,0.0003103533,0.3570665,0.0005368165,0.0002575642,0.000003629745,0.0008992374,2.781559e-7,0.02387693,0.03966947,0.0006794322,0.5763221],"study_design_scores_gemma":[0.006196251,0.0001131855,0.0888807,0.0001065875,0.0003450835,0.000008215498,0.0001372511,0.001814359,0.5952441,0.002253345,0.3045925,0.0003084735],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673918,0.001268418,0.02894376,0.001101029,0.0001293515,0.0005470437,6.739701e-7,0.000119819,0.0004980438],"genre_scores_gemma":[0.9346465,0.0001834952,0.06456544,0.000165696,0.00006284972,0.00003412425,0.00001183606,0.00001175105,0.0003182915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5760136,"threshold_uncertainty_score":0.3641626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04744179071526181,"score_gpt":0.3392559524644486,"score_spread":0.2918141617491868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}