{"id":"W2007293173","doi":"10.3109/10837450.2012.680598","title":"New immediate release formulation for deterring abuse of methadone","year":2012,"lang":"en","type":"article","venue":"Pharmaceutical Development and Technology","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paladin Labs (Canada)","funders":"","keywords":"Methadone; Immediate release; Abuse liability; Pharmacology; Drug; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001353835,0.0002477612,0.0002662216,0.0002504436,0.0001153131,0.0002037455,0.0003043767,0.0003348565,0.001743313],"category_scores_gemma":[0.0001810019,0.0001132203,0.0002161303,0.0000940576,0.0001191783,0.0002713561,0.000149076,0.0006125488,0.0004001109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001133,"about_ca_system_score_gemma":0.0001020163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001691323,"about_ca_topic_score_gemma":0.0005606341,"domain_scores_codex":[0.9999038,0.00001272944,0.000007596879,0.00001713453,0.00005009232,0.000008628256],"domain_scores_gemma":[0.9999188,0.00001356825,0.00002858232,0.000004551777,0.00002056955,0.00001382837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000227369,0.0002175438,0.0001827554,0.0003836676,0.00001632574,0.000323595,0.00005652498,0.0001094292,0.9647806,0.0003096376,0.000269361,0.03312312],"study_design_scores_gemma":[0.0005487485,0.01050029,0.008107061,0.0001276182,0.0001887221,0.004939092,0.00008958294,0.002168164,0.927783,0.0001474618,0.04534924,0.00005106522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9262761,0.02882323,0.0345277,0.0006392371,0.0003504157,0.0006046307,0.0004521553,0.0003152513,0.008011207],"genre_scores_gemma":[0.9277672,0.01125788,0.049382,0.0002956789,0.0001349937,0.0002932638,0.0003745896,0.00004093174,0.01045342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001743313,"threshold_uncertainty_score":0.005831957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04744179071526181,"score_gpt":0.3392559524644486,"score_spread":0.2918141617491868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}