{"id":"W2007299226","doi":"10.1016/j.ijpharm.2014.11.034","title":"Novel applications of ubiquinone biopolymer nanocarriers for preventive and regenerative therapeutics: The Saccharomyces cerevisiae paradigm","year":2014,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft","keywords":"Saccharomyces cerevisiae; Yeast; Hormesis; Biopolymer; Chemistry; Drug delivery; Reactive oxygen species; Nanocarriers; Biophysics; Biochemistry; Oxidative stress; Biology; Cell biology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003104167,0.0000918009,0.000124606,0.0000376905,0.00006422112,0.00001915818,0.000243765,0.00003853838,0.000004080842],"category_scores_gemma":[0.00003549811,0.00006371088,0.0001036913,0.00003720456,0.0001268567,0.000006511289,0.00006565049,0.00006798,2.341022e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001102959,"about_ca_system_score_gemma":0.00003802749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002568206,"about_ca_topic_score_gemma":0.000003455991,"domain_scores_codex":[0.9993654,0.00004377349,0.0002501805,0.00009995532,0.0001502455,0.00009041606],"domain_scores_gemma":[0.9991326,0.00009525221,0.0003188833,0.00008528268,0.0003291037,0.00003885304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002724494,0.00009599944,0.0004986313,0.00002310475,0.001094153,2.873637e-7,0.0003189385,0.00007551551,0.9770694,0.002535717,0.001194696,0.0168211],"study_design_scores_gemma":[0.001161973,0.0002454664,0.0001982144,0.00002543633,0.0001374303,0.00004495731,0.0002006664,0.0004737325,0.7858036,0.0003135585,0.2113102,0.00008472451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5811042,0.02845529,0.3775721,0.009654899,0.00149974,0.001118479,0.0002960915,0.000006930556,0.0002922441],"genre_scores_gemma":[0.9956795,0.001795061,0.001170431,0.0005321781,0.0006923081,0.00002066268,0.000009200756,0.00001001713,0.0000906534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4145753,"threshold_uncertainty_score":0.2598054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853209026935192,"score_gpt":0.3349071811286842,"score_spread":0.3163750908593323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}