{"id":"W2007361730","doi":"10.1016/j.jim.2012.06.003","title":"Defining TNF-α and IL-1β induced nascent proteins: Combining bio‐orthogonal non‐canonical amino acid tagging and proteomics","year":2012,"lang":"en","type":"article","venue":"Journal of Immunological Methods","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Manitoba Medical Service Foundation; American Heart Association","keywords":"Proteomics; Computational biology; Tumor necrosis factor alpha; Non canonical; Amino acid; Biochemistry; Chemistry; Biology; Cell biology; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009075938,0.0006624486,0.0003120381,0.0002414219,0.0002843794,0.0008903065,0.0003072198,0.0005198343,0.0005002758],"category_scores_gemma":[0.0004982433,0.0003485564,0.0003590771,0.000217615,0.0005017694,0.0006381341,0.0005029905,0.001295156,0.0004547113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006095663,"about_ca_system_score_gemma":0.0004640553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000358111,"about_ca_topic_score_gemma":0.000928296,"domain_scores_codex":[0.9996334,0.00007592171,0.00003119626,0.00009311752,0.00008961619,0.0000767034],"domain_scores_gemma":[0.9994668,0.0001358003,0.0001423957,0.00007072162,0.00009703352,0.00008724373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007553392,0.000009156071,0.00005766938,0.0000205339,0.000002156735,0.0000198706,0.00001525534,0.00004258661,0.9988105,0.000273551,0.00001373226,0.0006594594],"study_design_scores_gemma":[0.000006882944,0.00004059785,0.0002609274,0.000003214124,0.000005276234,0.00007243882,0.0000115108,0.0005084797,0.9981803,0.00007666797,0.0008303651,0.000003345253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8493656,0.001942778,0.145196,0.000286917,0.0001694505,0.0001940308,0.0004002619,0.0002461283,0.002198835],"genre_scores_gemma":[0.8731607,0.002412558,0.11669,0.0003154542,0.00005877332,0.0002454956,0.00113789,0.0002339937,0.005745078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009075938,"threshold_uncertainty_score":0.004799902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02950133361455832,"score_gpt":0.3223099216404855,"score_spread":0.2928085880259272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}