{"id":"W2007384031","doi":"10.1111/imm.12033","title":"Differential requirements of <scp>CD</scp>4<sup>+</sup><scp>T</scp>‐cell signals for effector cytotoxic T‐lymphocyte (<scp>CTL</scp>) priming and functional memory <scp>CTL</scp> development at higher <scp>CD</scp>8<sup>+</sup><scp>T</scp>‐cell precursor frequency","year":2012,"lang":"en","type":"article","venue":"Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Saskatchewan","keywords":"CTL*; Cytotoxic T cell; Priming (agriculture); CD8; CD40; Biology; Memory T cell; Immunology; T cell; Immune system; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","sts","research_integrity"],"category_scores_codex":[0.003903817,0.004666058,0.005608519,0.002785971,0.003389267,0.0004617723,0.003591344,0.005534431,0.000575441],"category_scores_gemma":[0.00750535,0.004642275,0.002266858,0.001730066,0.003379261,0.002189266,0.002607041,0.003414524,0.003331141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002353255,"about_ca_system_score_gemma":0.002265074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002732289,"about_ca_topic_score_gemma":0.00003141506,"domain_scores_codex":[0.9752452,0.005114918,0.005716547,0.004378343,0.001344768,0.008200178],"domain_scores_gemma":[0.9624974,0.02762381,0.004108489,0.003535308,0.001416186,0.0008187683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004775464,0.003914032,0.005918124,0.001298135,0.007706952,0.00008390563,0.01836689,0.0002790017,0.9193212,0.0003833382,0.03931088,0.002940037],"study_design_scores_gemma":[0.01940053,0.002830073,0.02491015,0.0005966047,0.001471233,0.0005310147,0.006110206,0.0000852206,0.6677279,0.0002681806,0.2756449,0.0004239334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8825217,0.09659085,0.001405455,0.00005601546,0.007399969,0.005943792,0.001043832,0.0009675735,0.004070735],"genre_scores_gemma":[0.8732324,0.00615605,0.002034106,0.000969656,0.001578787,0.003535336,0.003886076,0.001224437,0.1073832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2515932,"threshold_uncertainty_score":0.999333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039445470321186,"score_gpt":0.2365447688275256,"score_spread":0.2161503141243137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}