{"id":"W2007384031","doi":"10.1111/imm.12033","title":"Differential requirements of <scp>CD</scp>4<sup>+</sup><scp>T</scp>‐cell signals for effector cytotoxic T‐lymphocyte (<scp>CTL</scp>) priming and functional memory <scp>CTL</scp> development at higher <scp>CD</scp>8<sup>+</sup><scp>T</scp>‐cell precursor frequency","year":2012,"lang":"en","type":"article","venue":"Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Saskatchewan","keywords":"CTL*; Cytotoxic T cell; Priming (agriculture); CD8; CD40; Biology; Memory T cell; Immunology; T cell; Immune system; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181828,0.0002633603,0.0002119848,0.0001793141,0.0000796014,0.0004197711,0.0002620034,0.0003468386,0.001534721],"category_scores_gemma":[0.000292656,0.0001517861,0.0001308258,0.00009244775,0.0002267271,0.0003342483,0.0003094746,0.0006948715,0.0003944543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174424,"about_ca_system_score_gemma":0.0001505935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001856497,"about_ca_topic_score_gemma":0.0003478296,"domain_scores_codex":[0.9997267,0.00005282527,0.00002786336,0.0000482939,0.00005977798,0.00008442846],"domain_scores_gemma":[0.9995978,0.0001059437,0.00009461879,0.00003405286,0.00003762969,0.0001299278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485606,0.00001365249,0.0002873378,0.00002073211,0.00000185364,0.00003484896,0.000007593011,0.00005322155,0.9987726,0.00007302173,0.00001224324,0.0005742596],"study_design_scores_gemma":[0.00001723284,0.0004721583,0.01468731,0.000008429945,0.00002020765,0.0004215883,0.00004491571,0.001161029,0.9820744,0.00009104782,0.000995898,0.000005770473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977996,0.0003887991,0.0008046778,0.00002879764,0.000006549749,0.00001010487,0.0001217484,0.0000301494,0.0008095058],"genre_scores_gemma":[0.9977148,0.0002221052,0.001019864,0.00002943094,0.000009753644,0.00002776536,0.0003260339,0.00002120522,0.0006290071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001534721,"threshold_uncertainty_score":0.005134165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039445470321186,"score_gpt":0.2365447688275256,"score_spread":0.2161503141243137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}