{"id":"W2007412101","doi":"10.1161/circulationaha.113.008364","title":"Cardiac Fibroblast Glycogen Synthase Kinase-3β Regulates Ventricular Remodeling and Dysfunction in Ischemic Heart","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Medicine; GSK-3; Cardiac fibrosis; GSK3B; Fibrosis; Myofibroblast; SMAD; Ventricular remodeling; Fibroblast; Myocardial fibrosis; Extracellular matrix; Myocardial infarction; Internal medicine; Glycogen synthase; Transforming growth factor; Endocrinology; Cancer research; Phosphorylation; Cell biology; Glycogen; Biology; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982952,0.0003046731,0.000158653,0.0002032841,0.0001289896,0.0001969704,0.0001255989,0.0001624518,0.000780234],"category_scores_gemma":[0.0001186044,0.00007482411,0.0001556408,0.0001000419,0.0002536156,0.00009731954,0.0001520055,0.0003475441,0.0001661123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506471,"about_ca_system_score_gemma":0.0002271932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002857611,"about_ca_topic_score_gemma":0.0004884688,"domain_scores_codex":[0.999954,0.000009315915,0.000003322484,0.000007966926,0.00001260215,0.00001273287],"domain_scores_gemma":[0.9999431,0.000004829129,0.00002276654,0.000003310297,0.000007406716,0.00001859975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002352511,0.0002001948,0.01242507,0.0003183055,0.00006540319,0.0009223237,0.0001134296,0.0003252487,0.9624079,0.0008434218,0.001204413,0.01882181],"study_design_scores_gemma":[0.0007235542,0.001939855,0.5142984,0.0001806412,0.0003542732,0.003217275,0.0003256683,0.002254973,0.4623842,0.002598137,0.01168349,0.00003954884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748399,0.01773576,0.002449347,0.0005228025,0.0001225889,0.00003927811,0.0003087557,0.0001224377,0.003859153],"genre_scores_gemma":[0.9926682,0.005254394,0.000580496,0.0001291444,0.00004358654,0.0000384812,0.0001833624,0.000007424293,0.001094909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000780234,"threshold_uncertainty_score":0.002610087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059888094145444,"score_gpt":0.2272635045470273,"score_spread":0.2166646236055728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}