{"id":"W2007433513","doi":"10.1016/j.cell.2012.03.030","title":"RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":456,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Telomere; Biology; Fragility; DNA replication; Helicase; Nuclease; Genetics; DNA; Telomere-binding protein; Cell biology; Gene; DNA-binding protein; Chemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004064256,0.0004759092,0.0004384216,0.0005382246,0.0003697808,0.0006853414,0.0009146415,0.0008355236,0.005454518],"category_scores_gemma":[0.0004577078,0.0002820287,0.0004253888,0.0001473518,0.0005819444,0.0004225965,0.000487644,0.001593053,0.001809213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004461588,"about_ca_system_score_gemma":0.0004536609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003800533,"about_ca_topic_score_gemma":0.0006886878,"domain_scores_codex":[0.9997478,0.00003317245,0.00001969448,0.00006776163,0.00006054068,0.00007105679],"domain_scores_gemma":[0.9996879,0.00005538476,0.00008816712,0.00003870479,0.00003358564,0.00009619918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000647721,0.0001051249,0.0004462156,0.0001080838,0.00003268177,0.0001586369,0.00002791054,0.0001955289,0.9905702,0.0006622581,0.0005493911,0.006496205],"study_design_scores_gemma":[0.000122458,0.0004400662,0.002218024,0.00001418582,0.00002923509,0.0005150958,0.00004264655,0.0008406871,0.985072,0.0001655055,0.01052892,0.00001116262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768058,0.009381413,0.005085859,0.001461369,0.0002683474,0.00004973435,0.0005500931,0.000876595,0.005520708],"genre_scores_gemma":[0.9854971,0.001418109,0.002289216,0.0004087662,0.00006760759,0.00003568266,0.000743642,0.0001274255,0.009412528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005454518,"threshold_uncertainty_score":0.01824713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899589940362242,"score_gpt":0.2715630741957616,"score_spread":0.2525671747921392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}