{"id":"W2007433513","doi":"10.1016/j.cell.2012.03.030","title":"RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":456,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Telomere; Biology; Fragility; DNA replication; Helicase; Nuclease; Genetics; DNA; Telomere-binding protein; Cell biology; Gene; DNA-binding protein; Chemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00038092,0.0003544284,0.0005242225,0.000225223,0.0001429545,0.00005393933,0.0001737553,0.000160323,0.000462475],"category_scores_gemma":[0.0001867664,0.0002944061,0.00009505897,0.0004158345,0.0001565102,0.0002613432,0.0001362887,0.0004714819,0.0007169013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249739,"about_ca_system_score_gemma":0.00009081775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001565149,"about_ca_topic_score_gemma":0.00002872119,"domain_scores_codex":[0.9979101,0.00007066861,0.0003743484,0.00044792,0.0003765249,0.0008204057],"domain_scores_gemma":[0.9982241,0.0001676889,0.00009647838,0.000517712,0.0001066245,0.000887382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001095141,0.002625302,0.5637065,0.001730705,0.0001902868,0.00042215,0.01312821,0.000002952598,0.2944386,0.001874443,0.04118788,0.07959788],"study_design_scores_gemma":[0.002496044,0.0006547213,0.6086173,0.0004470773,0.0002525835,0.000515849,0.005773351,0.0000836297,0.1224147,0.0002254969,0.2573512,0.001167956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871046,0.002131769,0.0002095819,0.001026752,0.0005806839,0.0005205156,0.000027226,0.0001332915,0.00826557],"genre_scores_gemma":[0.992266,0.000357377,0.001638604,0.002251065,0.000543205,0.00002603365,0.00003408759,0.00005525102,0.002828401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2161634,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899589940362242,"score_gpt":0.2715630741957616,"score_spread":0.2525671747921392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}