{"id":"W2007457347","doi":"10.1089/gte.2006.0518","title":"The Use of Ancestral Haplotypes in the Molecular Diagnosis of Familial Breast Cancer","year":2007,"lang":"en","type":"article","venue":"Genetic Testing","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Shared Health","funders":"","keywords":"Haplotype; Genetics; Biology; Linkage disequilibrium; MSH2; Breast cancer; MLH1; Genotyping; Gene; Allele; Cancer; Genotype; Colorectal cancer; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833305,0.00008875586,0.00008404144,0.00002564592,0.00005536379,0.00001245803,0.000249999,0.00005708041,0.000002757459],"category_scores_gemma":[0.0002779344,0.00006132486,0.0000428586,0.0002336812,0.0001771461,0.000002357334,0.00005371749,0.00006553598,2.971521e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001839338,"about_ca_system_score_gemma":0.0001302917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526652,"about_ca_topic_score_gemma":0.0006799871,"domain_scores_codex":[0.9991455,0.00005593272,0.0002790982,0.000165545,0.00014953,0.0002043737],"domain_scores_gemma":[0.9992229,0.0002075589,0.0001340292,0.0002930493,0.0001232246,0.00001920002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004366174,0.00004706529,0.585369,0.00002181989,0.00003445605,0.000005280029,0.0002096053,0.01317191,0.2881719,0.00004142832,0.0002568545,0.1126271],"study_design_scores_gemma":[0.0002139951,0.00008273024,0.8241394,0.00003816658,0.00002353209,0.00002138161,0.000164241,0.0002091662,0.1730123,0.00006542398,0.001931254,0.00009850557],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964091,0.002366314,0.000682817,0.0001714953,0.0001045191,0.0001570807,0.00003136406,0.000003225594,0.00007413553],"genre_scores_gemma":[0.9935135,0.0001897708,0.006000223,0.000121028,0.0001072204,0.00004333959,0.000003182646,0.00001265445,0.000009117168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2387704,"threshold_uncertainty_score":0.2500755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04316075619140967,"score_gpt":0.2968924416283208,"score_spread":0.2537316854369112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}