{"id":"W2007457347","doi":"10.1089/gte.2006.0518","title":"The Use of Ancestral Haplotypes in the Molecular Diagnosis of Familial Breast Cancer","year":2007,"lang":"en","type":"article","venue":"Genetic Testing","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Shared Health","funders":"","keywords":"Haplotype; Genetics; Biology; Linkage disequilibrium; MSH2; Breast cancer; MLH1; Genotyping; Gene; Allele; Cancer; Genotype; Colorectal cancer; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001818092,0.0002391231,0.0002745345,0.001879749,0.0002793883,0.0003277733,0.0002284845,0.0002354057,0.0009091356],"category_scores_gemma":[0.003387244,0.0001510975,0.0001276902,0.0007204758,0.0004248123,0.0003217744,0.000749943,0.0002847462,0.0002614998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271567,"about_ca_system_score_gemma":0.0002195578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005870761,"about_ca_topic_score_gemma":0.001248816,"domain_scores_codex":[0.9988045,0.0006985007,0.00006737217,0.0001882474,0.0001525338,0.0000888921],"domain_scores_gemma":[0.9990234,0.0004512955,0.0002177899,0.0001277307,0.00007849676,0.0001012388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008428534,0.00008287569,0.8634805,0.0001029396,0.00007962147,0.001157552,0.0004894861,0.0008125707,0.04327694,0.000458669,0.0001997294,0.08901634],"study_design_scores_gemma":[0.00008782501,0.001446522,0.9451382,0.00008716342,0.0002721682,0.01586557,0.0004402536,0.004147318,0.02597089,0.001545676,0.004960368,0.00003807597],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922963,0.002050109,0.004074776,0.00007106819,0.00001141387,0.00003700521,0.0001247969,0.00002012472,0.001314474],"genre_scores_gemma":[0.9931879,0.0007027264,0.005747609,0.00002010735,0.00001196803,0.0000202684,0.0001156934,0.00000419988,0.0001895468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879749,"threshold_uncertainty_score":0.009615123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04316075619140967,"score_gpt":0.2968924416283208,"score_spread":0.2537316854369112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}