{"id":"W2007461418","doi":"10.1371/journal.pone.0013395","title":"Somatic Point Mutations in mtDNA Control Region Are Influenced by Genetic Background and Associated with Healthy Aging: A GEHA Study","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Max-Planck-Institut für demografische Forschung; Université de Montpellier; Fondazione Italiana per la Ricerca sul Cancro; Università degli Studi di Sassari; Chinese Academy of Sciences; Queen's University Belfast; Syddansk Universitet; Queen's University; European Commission; Universiteit Leiden; Newcastle University; National Research Centre; National Institute for Health and Care Research; Instytut Biologii Doswiadczalnej im. M. Nenckiego PAN; Wellcome Trust","keywords":"Heteroplasmy; Mitochondrial DNA; Genetics; Biology; Somatic cell; mtDNA control region; Lineage (genetic); Longevity; Point mutation; Mutation; Allele; Gene; Haplotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002856051,0.0002903191,0.0002432345,0.0007578597,0.0003161939,0.0002167653,0.0001100583,0.0002425557,0.001130556],"category_scores_gemma":[0.0005502352,0.0001170225,0.0001691685,0.0004167892,0.0002934307,0.0001297903,0.0003271258,0.0001513141,0.0001480021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000086015,"about_ca_system_score_gemma":0.0001006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024434,"about_ca_topic_score_gemma":0.0008566697,"domain_scores_codex":[0.9998666,0.00003194369,0.000007835892,0.00004104888,0.00002209124,0.00003043917],"domain_scores_gemma":[0.9997037,0.00007324192,0.00008462684,0.00005021247,0.00002843435,0.00005971096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001581442,0.0001390108,0.887279,0.00003187433,0.0002118645,0.003621905,0.0008936697,0.0001425143,0.09540024,0.0001801902,0.00009162266,0.01042667],"study_design_scores_gemma":[0.000008430426,0.0003620676,0.993993,0.000003663577,0.00006435166,0.003160608,0.0001544181,0.0002013816,0.001609742,0.0000649947,0.0003722608,0.00000505684],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996356,0.0001122247,0.0001168666,0.000004612363,9.123709e-7,0.000001849248,0.00002150258,0.000001457598,0.0001049694],"genre_scores_gemma":[0.999582,0.00008334362,0.0001008277,0.000007692291,0.00000554592,0.000002096863,0.00005834803,0.000001917186,0.0001581552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130556,"threshold_uncertainty_score":0.003782094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484637897182203,"score_gpt":0.2471880132629943,"score_spread":0.2223416342911722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}